Tao Zhirui, Chen Zhiqin, Zeng Xiaochen, Cui Jiujie, Quan Ming
Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200123, China.
Department of Oncology and State Key Laboratory of Systems Medicine for Cancer of Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Cancer Lett. 2024 Dec 28;611:217433. doi: 10.1016/j.canlet.2024.217433.
The nervous system governs both ontogeny and oncology. Foundational discoveries have clarified the direct communication of neurotransmitters with tumors and indirect interactions through neural effects on the immune system and the tumor microenvironment. Meantime, the nervous system is susceptible to cancer and its treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is the most common side effects that significantly reduce the efficacy of anti-cancer treatment and patients' quality of life by leading to dose reduction or early cessation of chemotherapy. However, there are no effective strategies to reverse or treat CIPN. A better understanding of the mechanisms is expected to enable the development of the next generation of therapies. Here, we summarize the recent important studies on clinical manifestations, risk factors, prediction, pathogenesis, prevention, and treatment of CIPN. We also provide perspectives and insights regarding the rationales of bidirectional interactions between cancer and the nervous system.
神经系统对个体发育和肿瘤学均有调控作用。基础研究发现已阐明神经递质与肿瘤的直接通讯以及通过对免疫系统和肿瘤微环境的神经效应产生的间接相互作用。与此同时，神经系统易受癌症及其治疗的影响。化疗引起的周围神经病变（CIPN）是最常见的副作用，通过导致化疗剂量减少或提前终止，显著降低抗癌治疗的疗效和患者的生活质量。然而，目前尚无有效的策略来逆转或治疗CIPN。对其机制的更好理解有望推动下一代疗法的开发。在此，我们总结了近期关于CIPN临床表现、危险因素、预测、发病机制、预防和治疗的重要研究。我们还提供了关于癌症与神经系统双向相互作用原理的观点和见解。
