Lilley Thomas, Camera Donny M, Kwa Faith A A
Department of Biomedical, Health and Exercise Sciences, Swinburne University of Technology, Melbourne, Australia.
Department of Biomedical, Health and Exercise Sciences, Swinburne University of Technology, Melbourne, Australia.
Drug Discov Today. 2025 Jan;30(1):104283. doi: 10.1016/j.drudis.2024.104283. Epub 2024 Dec 28.
Skeletal muscle health relies on the production of adenosine triphosphate (ATP) in the mitochondria. ATP production is accompanied by oxidative phosphorylation, which generates reactive oxygen species (ROS). When there is an imbalance in ROS levels, oxidative stress and subsequent mitochondrial dysfunction, mitochondrial myopathies including sarcopenia, chronic progressive external ophthalmoplegia, and proximal myopathy can result. Such incurable myopathies are characterised by aberrant metabolism, limited ATP production, and muscle atrophy. Broccoli-derived sulforaphane has emerged as a novel treatment for mitochondrial myopathies because of its antioxidant and anti-inflammatory properties. This review discusses preclinical studies that reveal sulforaphane's potential therapeutic benefits and limitations in treating mitochondrial myopathies.
骨骼肌健康依赖于线粒体中三磷酸腺苷（ATP）的产生。ATP的产生伴随着氧化磷酸化，而氧化磷酸化会产生活性氧（ROS）。当ROS水平失衡时，会导致氧化应激及随后的线粒体功能障碍，进而引发包括肌肉减少症、慢性进行性眼外肌麻痹和近端肌病在内的线粒体肌病。这类无法治愈的肌病的特征是代谢异常、ATP产生受限和肌肉萎缩。西兰花衍生的萝卜硫素因其抗氧化和抗炎特性，已成为线粒体肌病的一种新型治疗方法。这篇综述讨论了临床前研究，这些研究揭示了萝卜硫素在治疗线粒体肌病方面的潜在治疗益处和局限性。
