Zhu Mengyue, Liu Min, Lu Chunlei, He Dafeng, Li Jiao, Xu Xia, Cui Ying, Zhao Chuanyan, Xu Jun, Zhou Gang, Mou Hongbin, Bi Guangyu, Liu Changhua, Wang Rong
Nephrology Department, Northern Jiangsu People's Hospital, Yangzhou, China.
The Affiliated Suqian Hospital of Xuzhou Medical University and Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian, China.
BMC Cardiovasc Disord. 2024 Dec 31;24(1):761. doi: 10.1186/s12872-024-04452-3.
There is little research on cardiorenal anemia syndrome (CRAS) in China. This study was to describe the characteristics of patients with CRAS and to explore risk factors of all-cause death.
A total of 81,795 patients were hospitalized from August 2012 to August 2021 in the nephrology department and cardiology department, of which 820 patients with CRAS were recruited into this study. The 820 patients were divided into three groups based on New York Heart Association (NYHA) functional class: a NYHA Class II group (n = 124), a NYHA Class III group (n = 492), and a NYHA Class IV group (n = 204). Demographics and laboratory tests were collected and risk factors of all-cause death were analyzed. The primary endpoint of the study was all-cause death.
820 patients were included, with a median age of 65.00 (51.00-75.00) years and 61.2% were men. The median follow-up was 27.0 (13.0-51.0) months. 416 (50.7%) patients died during follow-up. Age, smoking history, cerebral infarction, NYHA functional class, albumin, serum creatinine (SCr), left ventricular end-diastolic diameter (LVEDD), and left ventricular ejection fraction (LVEF) remained independent predictors of all-cause mortality risk in patients with CRAS (P < 0.05) after adjusting to the potential confounders.
In patients with CRAS, older age, smoking history, and more advanced systolic heart failure and renal failure correlated with worse clinical outcomes at follow-up.
中国关于心肾贫血综合征（CRAS）的研究较少。本研究旨在描述CRAS患者的特征，并探讨全因死亡的危险因素。
2012年8月至2021年8月期间，共有81795名患者在肾内科和心内科住院，其中820例CRAS患者被纳入本研究。根据纽约心脏协会（NYHA）心功能分级，将这820例患者分为三组：NYHAⅡ级组（n = 124）、NYHAⅢ级组（n = 492）和NYHAⅣ级组（n = 204）。收集人口统计学和实验室检查数据，并分析全因死亡的危险因素。本研究的主要终点是全因死亡。
纳入820例患者，中位年龄为65.00（51.00 - 75.00）岁，男性占61.2%。中位随访时间为27.0（13.0 - 51.0）个月。416例（50.7%）患者在随访期间死亡。在调整潜在混杂因素后，年龄、吸烟史、脑梗死、NYHA心功能分级、白蛋白、血清肌酐（SCr）、左心室舒张末期内径（LVEDD）和左心室射血分数（LVEF）仍是CRAS患者全因死亡风险的独立预测因素（P < 0.05）。
在CRAS患者中，年龄较大、有吸烟史以及更严重的收缩性心力衰竭和肾衰竭与随访时更差的临床结局相关。
