Liao Jingxian, Shen Xiaozhu, Du Zhiqiang, Miao Lei
Department of Geriatrics, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, China.
Department of Critical Care Medicine, The Second People's Hospital of Lianyungang, Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu, China.
Front Aging. 2024 Dec 16;5:1478355. doi: 10.3389/fragi.2024.1478355. eCollection 2024.
With the global aging population, community-acquired pneumonia and delirium are increasingly critical health issues among the elderly. The Laboratory Frailty Index provides an objective measure of frailty. This study explores its capacity in predicting delirium and examines the interplay between frailty and nutritional status in elderly patients with community-acquired pneumonia.
This retrospective study included 481 elderly patients aged 75 and above diagnosed with community-acquired pneumonia. The Laboratory Frailty Index was calculated by dividing the sum of abnormal indicator scores by the total number of test indicators, resulting in a score ranging from 0 to 1, with higher values indicating greater frailty.
Higher Laboratory Frailty Index scores were associated with an increased risk of delirium. The index's predictive accuracy improved when combined with nutritional assessments. Patients experiencing malnutrition alongside higher frailty scores exhibited a higher risk of adverse outcomes. Nutritional status mediated the relationship between frailty and delirium, underlining the significance of addressing both variables.
The Laboratory Frailty Index is a robust predictor of delirium in elderly patients with community-acquired pneumonia. These findings provide valuable insights for the early identification and intervention of delirium in clinical settings.
随着全球人口老龄化，社区获得性肺炎和谵妄在老年人中日益成为关键的健康问题。实验室虚弱指数提供了一种客观的虚弱衡量指标。本研究探讨其预测谵妄的能力，并研究社区获得性肺炎老年患者中虚弱与营养状况之间的相互作用。
这项回顾性研究纳入了481名年龄在75岁及以上、被诊断为社区获得性肺炎的老年患者。实验室虚弱指数通过将异常指标得分总和除以测试指标总数来计算，得分范围为0至1，得分越高表明虚弱程度越高。
较高的实验室虚弱指数得分与谵妄风险增加相关。该指数与营养评估相结合时，预测准确性提高。营养不良且虚弱得分较高的患者出现不良结局的风险更高。营养状况介导了虚弱与谵妄之间的关系，凸显了同时处理这两个变量的重要性。
实验室虚弱指数是社区获得性肺炎老年患者谵妄的有力预测指标。这些发现为临床环境中谵妄的早期识别和干预提供了有价值的见解。
