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可溶性CD52通过人类精液介导免疫抑制。

Soluble CD52 mediates immune suppression by human seminal fluid.

作者信息

Harrison Leonard C, Stone Natalie L, Bandala-Sanchez Esther, Huntington Nicholas D, McLachlan Robert I, Rautela Jai, O'Bryan Moira K

机构信息

Population Heath and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

The University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.

出版信息

Front Immunol. 2024 Dec 16;15:1497889. doi: 10.3389/fimmu.2024.1497889. eCollection 2024.

DOI:10.3389/fimmu.2024.1497889
PMID:39737172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11682959/
Abstract

Seminal fluid provides for the carriage and nutrition of sperm, but also modulates immunity to prevent allo-rejection of sperm by the female. Immune suppression by seminal fluid has been associated with extracellular vesicles, originally termed prostasomes, which contain CD52, a glycosylated glycophosphoinositol-anchored peptide released from testicular epithelial cells. Previously, we reported that human T cell-derived CD52, bound to the danger-associated molecular pattern protein, high mobility group box 1 (HMGB1), suppresses T cell function via the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor. Here we show that human seminal fluid contains high concentrations of CD52 complexed with HMGB1, which mediates T cell suppression indirectly via Siglec-7 on antigen-presenting cells. Proliferation of natural killer (NK) cells, which express Siglec-7 and play a key role in the immune defence of the uterus, was directly suppressed by seminal fluid CD52. These findings elucidate a critical function of seminal fluid to suppress cellular immunity and facilitate reproduction.

摘要

精液不仅为精子提供运输和营养，还能调节免疫，防止女性对精子产生同种异体排斥反应。精液的免疫抑制作用与细胞外囊泡有关，这些囊泡最初被称为前列腺小体，其中含有CD52，一种从睾丸上皮细胞释放的糖基化糖磷脂酰肌醇锚定肽。此前，我们报道过，与危险相关分子模式蛋白高迁移率族蛋白B1（HMGB1）结合的人T细胞衍生的CD52，通过抑制性唾液酸结合免疫球蛋白样凝集素10（Siglec-10）受体抑制T细胞功能。在此，我们表明，人精液中含有高浓度与HMGB1复合的CD52，其通过抗原呈递细胞上的Siglec-7间接介导T细胞抑制。精液中的CD52直接抑制了自然杀伤（NK）细胞的增殖，NK细胞表达Siglec-7，在子宫免疫防御中起关键作用。这些发现阐明了精液在抑制细胞免疫和促进生殖方面的关键功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/5c5d8e8bc63c/fimmu-15-1497889-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/3e5f34be3b70/fimmu-15-1497889-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/4741e3723bac/fimmu-15-1497889-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/779ad9c167b3/fimmu-15-1497889-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/c931936bb29d/fimmu-15-1497889-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/4b642b702bac/fimmu-15-1497889-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/67a298d0bce2/fimmu-15-1497889-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/5c5d8e8bc63c/fimmu-15-1497889-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/3e5f34be3b70/fimmu-15-1497889-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/4741e3723bac/fimmu-15-1497889-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/779ad9c167b3/fimmu-15-1497889-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/c931936bb29d/fimmu-15-1497889-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/4b642b702bac/fimmu-15-1497889-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/67a298d0bce2/fimmu-15-1497889-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92be/11682959/5c5d8e8bc63c/fimmu-15-1497889-g007.jpg

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本文引用的文献

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A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses.一组离散的受表观遗传学调控的人类自然杀伤细胞亚群介导了抗原特异性免疫反应。
Sci Immunol. 2020 Oct 16;5(52). doi: 10.1126/sciimmunol.aba6232.
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The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction.附睾的作用和附睾小体对哺乳动物生殖的贡献。
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The cancer-natural killer cell immunity cycle.癌症-自然杀伤细胞免疫周期。
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HLA-DR-expressing NK cells: Effective killers suspected for antigen presentation.表达 HLA-DR 的 NK 细胞：具有抗原呈递功能的有效杀伤细胞。
J Leukoc Biol. 2021 Feb;109(2):327-337. doi: 10.1002/JLB.3RU0420-668RR. Epub 2020 May 18.
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Siglec-10 expression is up-regulated in activated human CD4 T cells.Siglec-10 在活化的人 CD4 T 细胞中表达上调。
Hum Immunol. 2020 Feb-Mar;81(2-3):101-104. doi: 10.1016/j.humimm.2020.01.009. Epub 2020 Feb 9.
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CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.CD52 聚糖结合 HMGB1 的促炎 B 盒结构域，以结合 Siglec-10 受体并抑制人 T 细胞功能。
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7783-7788. doi: 10.1073/pnas.1722056115. Epub 2018 Jul 11.
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Siglec expression on the surface of human, bull and ram sperm.人、牛和公羊精子表面的 Siglec 表达。
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CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.CD52 抑制 Toll 样受体激活 NF-κB 并触发细胞凋亡以抑制炎症。
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Functional deficit of sperm and fertility impairment in men with antisperm antibodies.患有抗精子抗体的男性精子功能缺陷与生育能力受损
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