Karakusevic Anna, Foss Anna M
RJW&partners, The Old Sawmills, Filleigh, Devon, UK, EX32 0RN.
Faculty of Public Health and Policy, LSHTM, London, UK.
Ther Adv Vaccines Immunother. 2024 Dec 25;12:25151355241308313. doi: 10.1177/25151355241308313. eCollection 2024.
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, with HPV and HPV-related diseases representing a substantial disease burden. HPV vaccination has reduced HPV infections and HPV-related diseases; however, there is growing evidence of delayed or refused vaccination due to a lack of trust in vaccines. Understanding the factors that impact vaccine uptake will allow the development and implementation of successful vaccination programmes.
This study aimed to evaluate the acceptability of HPV vaccination among adolescents and parents in the United Kingdom (UK).
Systematic review.
Online databases (Embase, Medline and Cochrane) and grey literature sources were searched to identify publications pertaining to 'adolescents', 'parents', 'vaccine uptake', 'vaccine hesitancy' and 'barriers or facilitators to vaccination'. Searches were limited to English language and articles published specific to the United Kingdom between 2017 and 2023.
Following a review of 152 abstracts, 24 publications met the inclusion criteria. While HPV vaccination is widely accepted in the UK, with coverage reported ⩾80% in peer-reviewed literature, the UK Health Security Agency report that vaccine coverage estimates in England between 2020-2023 remain below 80% and are lower than pre-COVID levels. Several important barriers were identified that may impact vaccine uptake, including system-level (challenges with obtaining consent), psychological/behavioural (perception of HPV risk vs vaccine risks), and sociodemographic factors, with similar factors reported among adolescents and parents.
HPV vaccination coverage remains below pre-COVID levels in the UK and common barriers among adolescents and parents have been identified that must be addressed to improve coverage rates. There is currently limited evidence among adolescent boys to fully evaluate any differences in vaccination coverage, or barriers, compared to girls. More research is required into facilitators to vaccination (especially to address sociodemographic barriers), to identify approaches to tackle the barriers that currently impede HPV vaccination uptake.
人乳头瘤病毒（HPV）是全球最常见的性传播感染，HPV及与HPV相关的疾病构成了相当大的疾病负担。HPV疫苗接种已减少了HPV感染和与HPV相关的疾病；然而，越来越多的证据表明，由于对疫苗缺乏信任，导致疫苗接种延迟或被拒绝。了解影响疫苗接种率的因素将有助于制定和实施成功的疫苗接种计划。
本研究旨在评估英国青少年及其父母对HPV疫苗接种的接受程度。
系统评价。
检索在线数据库（Embase、Medline和Cochrane）及灰色文献来源，以确定与“青少年”、“父母”、“疫苗接种率”、“疫苗犹豫”以及“疫苗接种的障碍或促进因素”相关的出版物。检索限于2017年至2023年间以英文发表的、特定于英国的文章。
在对152篇摘要进行综述后，有24篇出版物符合纳入标准。虽然HPV疫苗接种在英国被广泛接受，同行评审文献报道的覆盖率⩾80%，但英国卫生安全局报告称，2020 - 2023年英格兰的疫苗覆盖率估计仍低于80%，且低于新冠疫情前的水平。确定了几个可能影响疫苗接种率的重要障碍，包括系统层面（获得同意方面的挑战）、心理/行为层面（对HPV风险与疫苗风险的认知）以及社会人口统计学因素，青少年和父母中均报告了类似因素。
英国的HPV疫苗接种覆盖率仍低于新冠疫情前的水平，已确定青少年和父母中存在的常见障碍，必须加以解决以提高覆盖率。目前，与女孩相比，关于青少年男孩疫苗接种覆盖率或障碍的差异，可供全面评估的证据有限。需要对疫苗接种的促进因素进行更多研究（特别是解决社会人口统计学障碍），以确定应对目前阻碍HPV疫苗接种的障碍的方法。
