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伊朗阿尔达比勒伊玛目医院关于导致尿路感染的11年回顾性队列研究的经验教训。

Lessons from an 11-year retrospective cohort study of causing UTI in Imam Hospital Ardabil, Iran.

作者信息

Shakib Pegah, Arzanlou Mohsen, Sobhi Pouria, Mojebi Mehdi, Bahrami Mohammad, Mahdizadeh Faraz, Asadi Leyla, Amanzadeh Masoud, Mohammadnia Alireza, Khademi Farzad, Ramazanzadeh Rashid

机构信息

Razi Herbal Medicines Research Center, Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

出版信息

Iran J Microbiol. 2024 Dec;16(6):737-744. doi: 10.18502/ijm.v16i6.17246.

Abstract

BACKGROUND AND OBJECTIVES

The global problem of urinary tract infections (UTIs) caused by antibiotic-resistant bacteria is due to limited treatment options. This study aimed to examine the prevalence, etiology, and management implications of causing UTI at Imam Hospital Ardabil, Iran.

MATERIALS AND METHODS

2340 samples of retrospective data on causing UTIs were collected at Imam Hospital in Ardabil, Iran, spanning from 2012 to 2022. The samples were cultured and isolated, and their antibiotic susceptibility was determined using standard laboratory methods and data were then organized and systematically categorized using Python.

RESULTS

It was found that the lowest level of resistance was related to nitrofurantoin, followed by imipenem. In 2018, the number of patients resistant to trimethoprim was the highest. Cephalexin and ciprofloxacin trends indicate the reduction of the line during this retrospective period. There was a significant correlation between wards and some antibiotics like Cefepime, Cefotaxime, Ceftazidime, and Trimethoprim (P-Value <0.05).

CONCLUSION

Significant correlations were identified between specific hospital wards and resistance to antibiotics. These findings underscore the need for continuous surveillance and tailored antibiotic stewardship programs to combat the rising trend of antibiotic resistance.

摘要

背景与目的

由抗生素耐药菌引起的尿路感染(UTIs)这一全球性问题是由于治疗选择有限。本研究旨在调查伊朗阿尔达比勒伊玛目医院引起UTI的患病率、病因及管理意义。

材料与方法

收集了伊朗阿尔达比勒伊玛目医院2012年至2022年期间2340份关于引起UTIs的回顾性数据样本。对样本进行培养和分离,并使用标准实验室方法确定其抗生素敏感性,然后使用Python对数据进行整理和系统分类。

结果

发现耐药性最低的是呋喃妥因,其次是亚胺培南。2018年,对甲氧苄啶耐药的患者数量最多。头孢氨苄和环丙沙星的趋势表明在这一回顾期内该品系有所减少。病房与一些抗生素如头孢吡肟、头孢噻肟、头孢他啶和甲氧苄啶之间存在显著相关性(P值<0.05)。

结论

在特定医院病房与抗生素耐药性之间发现了显著相关性。这些发现强调了持续监测和制定针对性抗生素管理计划以应对抗生素耐药性上升趋势的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ae/11682551/d57e887440b2/IJM-16-737-g001.jpg

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