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新型抗肿瘤药物制剂的研究进展

Research progress of novel anti-tumor drug formulations.

作者信息

Liu Yan, Guo Qie, Shi YunYan, Cui MengNa, Jing FanBo

机构信息

Department of Pharmacology, School of Basic Medicine, Qingdao University, Qingdao, China.

Department of Clinical Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

出版信息

Front Oncol. 2024 Dec 16;14:1507958. doi: 10.3389/fonc.2024.1507958. eCollection 2024.

DOI:10.3389/fonc.2024.1507958
PMID:39737395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11683012/
Abstract

Cancers have become the second leading cause of death worldwide, following cardiovascular diseases.Traditional anti- cancer strategies, including radiotherapy chemotherapy, surgery, and targeted therapies, have been widely used but are often reassessed due to their significant side effects and relatively low cure rate. Recently, the development of novel formulations for anti-tumor drugs has gained considerable attention, marking a pivotal step forward in cancer treatment advancements. These innovative formulations aim to enhance the therapeutic efficacy of anti-tumor drugs by employing advanced drug formulation technologies and delivery systems. In particular, nano-drug delivery systems (NDDS) have emerged as a promising approach to improve drug targeting, reduce side effects, and overcome drug resistance. This review highlights recent progress in NDDS for anti-tumor drug development and explores the future prospects of these advanced formulations in improving cancer treatment outcomes.

摘要

癌症已成为全球第二大死因，仅次于心血管疾病。传统的抗癌策略，包括放疗、化疗、手术和靶向治疗，已被广泛应用，但由于其显著的副作用和相对较低的治愈率，常常需要重新评估。近年来，新型抗肿瘤药物制剂的开发备受关注，标志着癌症治疗进展的关键一步。这些创新制剂旨在通过采用先进的药物制剂技术和递送系统来提高抗肿瘤药物的治疗效果。特别是，纳米药物递送系统（NDDS）已成为一种有前途的方法，可改善药物靶向性、减少副作用并克服耐药性。本综述重点介绍了NDDS在抗肿瘤药物开发方面的最新进展，并探讨了这些先进制剂在改善癌症治疗效果方面的未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/df3080c17675/fonc-14-1507958-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/c91c5efaba1a/fonc-14-1507958-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/811f3cd4a6bb/fonc-14-1507958-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/69203e19767e/fonc-14-1507958-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/df3080c17675/fonc-14-1507958-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/c91c5efaba1a/fonc-14-1507958-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/b62de4aea834/fonc-14-1507958-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/30474dd9fed7/fonc-14-1507958-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/514e5d8558c0/fonc-14-1507958-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/69203e19767e/fonc-14-1507958-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/322f/11683012/df3080c17675/fonc-14-1507958-g007.jpg

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本文引用的文献

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Biomimetic Ghost Nanomedicine-Based Optotheranostics for Cancer.仿生幽灵纳米医学癌症光热治疗一体化。
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Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics.
用于临床前肿瘤靶向纳米诊疗的生物启发和仿生癌细胞衍生膜纳米囊泡。
Cell Rep Phys Sci. 2023 Nov 15;4(11):101648. doi: 10.1016/j.xcrp.2023.101648.
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Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor.细胞因子基因疫苗疗法治疗脑肿瘤
Brain Sci. 2023 Oct 25;13(11):1505. doi: 10.3390/brainsci13111505.
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Optimal delivery of RNA interference by viral vectors for cancer therapy.病毒载体介导的 RNA 干扰在癌症治疗中的最佳传递。
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