Krasna I H, Thompson D A
J Pediatr Surg. 1985 Feb;20(1):30-3. doi: 10.1016/s0022-3468(85)80387-0.
Although splenic autotransplantation is successful in mice and rats, with regeneration occurring in any location, no extensive study had been performed on dogs. We transplanted the spleen into subcutaneous and intraperitoneal locations on 40 dogs. Four to six months later, splenic scanning and reexploration was carried out. Spleens were removed, weighed, and microscopic sections were made. Months later, no uptake was present on scanning, weight was less than 6% of original weight, and little identifiable splenic tissue was present on microscopic sections. When 15 small sections were transplanted to the omentum in a "necklace" fashion, good uptake and preservation were seen after six months. The small amount of spleen transplanted by this method, however, makes this an unsatisfactory option. We conclude, therefore that our large-animal experiments do not provide a basis on which to recommend autotransplantation of the spleen in humans. Preservation of splenic tissue by splenorrhaphy is still the treatment of choice.
虽然脾自体移植在小鼠和大鼠中取得了成功，移植后的脾脏可在任何位置再生，但此前尚未对狗进行过广泛研究。我们将脾脏移植到40只狗的皮下和腹腔内。4至6个月后，进行脾脏扫描和再次探查。取出脾脏，称重，并制作显微切片。数月后，扫描显示无摄取，重量不到原始重量的6%，显微切片上几乎看不到可识别的脾组织。当以“项链”方式将15个小切片移植到网膜时，6个月后可见良好的摄取和保存情况。然而，用这种方法移植的脾脏量很少，这使得它不是一个令人满意的选择。因此，我们得出结论，我们的大型动物实验没有为推荐人类进行脾脏自体移植提供依据。通过脾修补术保留脾组织仍然是首选的治疗方法。
