Jiang Wenbin, Wang Junlu, Robe Pierre A, Wei Min, Li Sen, Wang Rui, Zhan Qijia, Xiao Bo
Department of Neurosurgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 355, Luding Rd., Putuo District, Shanghai, China.
Department of Neurology and Neurosurgery, University Medical Center of Utrecht, Utrecht, The Netherlands.
Sci Rep. 2024 Dec 30;14(1):31687. doi: 10.1038/s41598-024-81512-w.
This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these symptoms. The study also explored the correlation between postoperative LUTS improvement and intraoperative electrophysiological findings. Prospective data were collected from a consecutive cohort of 247 children with SCP who underwent SDR and were retrospectively analyzed. Pre- and post-operative assessments included muscle tone, motor function, LUTS and intraoperative electrophysiology data were analyzed. Preoperatively, 94 patients (38.1%) had LUTS, and the severity of LUTS negatively correlated with motor function (R=-0.32, P < 0.0001). After SDR, muscle tone decreased, motor function improved (P < 0.0001), and LUTS resolved in 49/94 patients (52.1%). LUTS improvement correlated with a higher proportion of sensory nerves evoking anal sphincter EMG > 20µV. SDR effectively reduces spasticity, improves motor function, and alleviates LUTS in most children with SCP. Intraoperative neurophysiology may predict improvements, warranting further research.
本研究调查了痉挛性脑瘫(SCP)患儿下尿路症状(LUTS)的患病率和严重程度,并评估了选择性背根切断术(SDR)缓解这些症状的效果。该研究还探讨了术后LUTS改善与术中电生理结果之间的相关性。前瞻性数据收集自连续247例接受SDR的SCP患儿队列,并进行回顾性分析。分析术前和术后评估包括肌张力、运动功能、LUTS和术中电生理数据。术前,94例患者(38.1%)有LUTS,LUTS严重程度与运动功能呈负相关(R=-0.32,P<0.0001)。SDR后,肌张力降低,运动功能改善(P<0.0001),94例患者中有49例(52.1%)LUTS症状消失。LUTS改善与引起肛门括约肌肌电图>20µV的感觉神经比例较高相关。SDR有效降低痉挛,改善运动功能,并缓解大多数SCP患儿的LUTS。术中神经生理学可能预测改善情况,值得进一步研究。