Foulady-Dehaghi R, Sohrabnezhad Sh, Hadavi M
Faculty of Chemistry, University of Guilan, P.O. Box 1914, Rasht, Iran.
Department of Biology, Faculty of Science, University of Guilan, P.O. Box 1914, Rasht, Iran.
Sci Rep. 2024 Dec 30;14(1):32077. doi: 10.1038/s41598-024-83614-x.
A novel polyimide-bridge covalent organic framework-based (PI-COF) hybrid was synthesized through simple green chemistry between PI-COF and MCM-NH monomers as a pH-sensitive anticancer curcumin (C) delivery system. The synthesized nanohybrid was crystalline in nature with an improved surface area and pore volume compared to the base COF, certified by powder X-ray diffraction spectroscopy and Brunauer-Emmett-Teller technique. Kinetically controlled and sustained curcumin release profiles were investigated using the as-prepared curcumin-loaded drug delivery systems (C@DDSs) in neutral and acidic pH media. C-loaded hybrid nanostructure prepared via the solvent-free drug loading process displayed a high entrapment efficiency (35.96%) and improved release in the acidic environment specific to cancer cells (pH = 4.5: 36.8%, pH = 7.4: 15.27%). In conclusion, we illustrated the utility of C@DDS as an in vitro drug delivery system in MDA-MB-231 cells. C@DDSs represented the time-dependent release of curcumin followed by cell death. Therefore, the reported PI-COF/MCM-NH2 system can be considered a new biocompatible carrier in COF research as a sensitive drug delivery system.
通过PI-COF与MCM-NH单体之间简单的绿色化学方法，合成了一种新型的基于聚酰亚胺桥共价有机框架（PI-COF）的杂化物，作为一种对pH敏感的抗癌姜黄素（C）递送系统。通过粉末X射线衍射光谱和布鲁诺尔-埃米特-泰勒技术证明，合成的纳米杂化物本质上是结晶的，与基础COF相比，其表面积和孔体积有所改善。使用制备好的载姜黄素药物递送系统（C@DDSs）在中性和酸性pH介质中研究了动力学控制和持续的姜黄素释放曲线。通过无溶剂载药过程制备的载C杂化纳米结构显示出高包封率（35.96%），并在癌细胞特异性的酸性环境中改善了释放（pH = 4.5时：36.8%，pH = 7.4时：15.27%）。总之，我们阐述了C@DDS作为MDA-MB-231细胞体外药物递送系统的效用。C@DDSs表现出姜黄素的时间依赖性释放，随后导致细胞死亡。因此，所报道的PI-COF/MCM-NH2系统在COF研究中可被视为一种新型的生物相容性载体，作为一种敏感的药物递送系统。
