基于离心的阻力运动对整个月经周期和口服避孕药周期中骨（再）重塑标志物的影响。
Effect of eccentric-based resistance exercise on bone (re)modelling markers across the menstrual cycle and oral contraceptive cycle.
作者信息
Guisado-Cuadrado Isabel, Romero-Parra Nuria, Cupeiro Rocío, Elliott-Sale Kirsty J, Sale Craig, Peinado Ana B
机构信息
LFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain.
Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine. Faculty of Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain.
出版信息
Eur J Appl Physiol. 2025 May;125(5):1463-1473. doi: 10.1007/s00421-024-05693-y. Epub 2024 Dec 30.
PURPOSE
To investigate the acute effects of eccentric-based resistance exercise and sex-hormone fluctuations on P1NP and β-CTX-1 concentrations in premenopausal females.
METHODS
Nine eumenorrheic females and ten oral contraceptive (OC) users performed eccentric-based resistance exercise, consisted of 10 × 10 repetitions of parallel back squats with a 4-s eccentric phase, in the early-follicular (EFP), late-follicular (LFP) and mid-luteal (MLP) phases of the menstrual cycle (MC) or in the withdrawal (WP) and active pill-taking (APP) phases of the OC cycle.
RESULTS
17β-oestradiol (pg·ml) was lower in EFP (36.63 ± 29.93) compared to LFP (224.81 ± 233.81; p ≤ 0.001) and MLP (161.45 ± 110.08; p < 0.001) and higher in WP (24.857 ± 29.428) compared to APP (12.72 ± 13.36; p = 0.004). Progesterone (ng·ml-1) was higher in MLP (8.30 ± 5.23) compared to EFP (0.33 ± 0.33; p < 0.001) and LFP (0.21 ± 0.18; p < 0.001), no significant differences were observed between the WP and APP. In eumenorrheic females, β-CTX-1 (ng·ml) was lower in MLP (0.395 ± 0.126) compared to LFP (0.472 ± 0.137; p = 0.044). Comparing MC vs OC phases, eumenorrheic females had higher P1NP levels (ng·ml) compared to OC users: EFP (62.54 ± 13.13) vs APP (50.69 ± 8.91; p = 0.034), LFP (67.32 ± 18.96) vs WP (52.16 ± 10.72; p = 0.047), LFP vs APP (p = 0.025), MLP (67.51 ± 19.34; p = 0.049) vs WP, MLPvsAPP (p = 0.027). Exercise time effect showed lower β-CTX-1 concentrations 2 h post-exercise (MC: 0.376 ± 0.114, p < 0.001; OC: 0.340 ± 0.156, p = 0.030) compared to pre-exercise (MC: 0.485 ± 0.137; OC: 0.428 ± 0.188) in all participants.
CONCLUSIONS
β-CTX-1 concentrations were lower in the mid-luteal phase, emphasising the importance of standardizing bone marker measurements to a specific MC phase. OC users exhibited reduced P1NP levels, underscoring the need to investigate synthetic and endogenous hormones' impact on long-term bone structure and strength. Trial registration The study was registered at Clinicaltrials.gov NCT04458662 on 2 July 2020.
目的
研究离心抗阻运动和性激素波动对绝经前女性血清I型前胶原氨基端前肽（P1NP）和β-CTX-1浓度的急性影响。
方法
9名月经周期正常的女性和10名口服避孕药（OC）使用者在月经周期（MC）的卵泡早期（EFP）、卵泡晚期（LFP）和黄体中期（MLP）阶段，或在OC周期的撤药期（WP）和服药期（APP）进行离心抗阻运动，包括10组，每组10次平行后蹲，离心阶段持续4秒。
结果
与LFP（224.81±233.81；p≤0.001）和MLP（161.45±110.08；p<0.001）相比，EFP阶段的17β-雌二醇（pg·ml）较低，而与APP（12.72±13.36；p=0.004）相比，WP阶段的17β-雌二醇较高。与EFP（0.33±0.33；p<0.001）和LFP（0.21±0.18；p<0.001）相比，MLP阶段的孕酮（ng·ml-1）较高，WP和APP之间未观察到显著差异。在月经周期正常的女性中，与LFP（0.472±0.137；p=0.044）相比，MLP阶段的β-CTX-1（ng·ml）较低。比较MC期和OC期，月经周期正常的女性的P1NP水平（ng·ml）高于OC使用者：EFP（62.54±13.13）vs APP（50.69±8.91；p=0.034），LFP（67.32±18.96）vs WP（52.16±10.72；p=0.047），LFP vs APP（p=0.025），MLP（67.51±19.34；p=0.049）vs WP，MLP vs APP（p=0.027）。运动时间效应显示，与运动前（MC：0.485±0.137；OC：0.428±0.188）相比，所有参与者运动后2小时的β-CTX-1浓度较低（MC：0.376±0.114，p<0.001；OC：0.340±0.156，p=0.030）。
结论
黄体中期β-CTX-1浓度较低，强调了将骨标志物测量标准化到特定MC阶段的重要性。OC使用者的P1NP水平降低，突出了研究合成激素和内源性激素对长期骨骼结构和强度影响的必要性。试验注册该研究于2020年7月2日在Clinicaltrials.gov上注册，注册号为NCT04458662。
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