Cottereau M J, Poirier M F, Lôo H, Deniker P
Encephale. 1979;5(3):251-67.
Commercialized in the U.S.A. a few years ago, the loxapine succinate appears to be interesting among neuroleptic compounds. Used in 28 chronic schizophrenics, 19 of which were neuroleptic resistent patients, the parenteral route proved to be anti-psychotic and sedative in 26 patients. The usual daily dosages were between 100 and 200 mg. The local and general tolerances were good. The side effects were mild and essentially vegetative. The therapeutic efficiency seems to be better at the same dosages with the oral form than with the parenteral form.
几年前在美国实现商业化的丁二酸洛沙平,在抗精神病药物中似乎颇具吸引力。对28名慢性精神分裂症患者使用了该药,其中19名是抗精神病药物耐药患者,经证实,肠胃外给药途径对26名患者具有抗精神病和镇静作用。通常的每日剂量在100至200毫克之间。局部和全身耐受性良好。副作用轻微,主要是植物神经方面的。在相同剂量下,口服剂型的治疗效果似乎比肠胃外给药剂型更好。