Hooda Vishakha, Sharma Alpana
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Immunology. 2025 Mar;174(3):287-295. doi: 10.1111/imm.13886. Epub 2024 Dec 30.
The interaction between immune cells brings a consequence either on their role and functioning or the functioning of the other immune cells, modulating the whole mechanistic pathway. The interaction between natural killer (NK) cells and macrophages is one such interaction which is relatively less explored amongst diseased conditions. Their significance comes from their innate nature and secretion of large proportions of cytokines and chemokines which results in influencing adaptive immune responses. Their interplay can lead to several functional outcomes such as NK cell activation/inhibition, increased cytotoxicity and IFNγ release by NK cells, inhibition of macrophage function, etc. This paper delves into the interaction amongst NK cells and macrophages via different receptor-ligands and cytokines, particularly emphasising microbial infections and tumours. The review has the potential to uncover new insights and approaches that could lead to the development of innovative therapeutic tools and targets.
免疫细胞之间的相互作用会对它们自身的作用和功能或其他免疫细胞的功能产生影响，从而调节整个机制途径。自然杀伤（NK）细胞与巨噬细胞之间的相互作用就是这样一种相互作用，在疾病状态下相对较少被研究。它们的重要性源于其先天性以及大量细胞因子和趋化因子的分泌，这会影响适应性免疫反应。它们之间的相互作用可导致多种功能结果，如NK细胞的激活/抑制、NK细胞细胞毒性增加和IFNγ释放、巨噬细胞功能抑制等。本文通过不同的受体-配体和细胞因子深入探讨NK细胞与巨噬细胞之间的相互作用，尤其着重于微生物感染和肿瘤。该综述有潜力揭示新的见解和方法，从而推动创新治疗工具和靶点的开发。
