MCL-1表达在结直肠癌中的作用。 - Suppr | 超能文献

Effects of MCL-1 expression in colorectal cancer.

作者信息

Adams Jessamy, Stebbing Justin

机构信息

School of Life Sciences, Anglia Ruskin University, Cambridge, UK.

出版信息

Int J Cancer. 2025 Apr 15;156(8):1499-1500. doi: 10.1002/ijc.35308. Epub 2024 Dec 30.

DOI:10.1002/ijc.35308

Abstract

摘要

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

相似文献

1

Effects of MCL-1 expression in colorectal cancer.MCL-1表达在结直肠癌中的作用。

Int J Cancer. 2025 Apr 15;156(8):1499-1500. doi: 10.1002/ijc.35308. Epub 2024 Dec 30.

2

Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-X dual inhibitor that induces Bax-dependent apoptosis.Mcl-1 水平对人结直肠癌细胞对 APG-1252-M1 的敏感性有重要影响，APG-1252-M1 是一种新型的 Bcl-2/Bcl-X 双抑制剂，可诱导 Bax 依赖性细胞凋亡。

Neoplasia. 2022 Jul;29:100798. doi: 10.1016/j.neo.2022.100798. Epub 2022 Apr 21.

3

Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro.超越细胞死亡——抗凋亡 Bcl-2 蛋白调控结直肠癌细胞的体外迁移和侵袭。

PLoS One. 2013 Oct 3;8(10):e76446. doi: 10.1371/journal.pone.0076446. eCollection 2013.

4

The Interaction Between Cancer-associated Fibroblasts and Cancer Cells Enhances Bcl-xL and Mcl-1 in Colorectal Cancer.癌症相关成纤维细胞与癌细胞的相互作用增强了结直肠癌中的 Bcl-xL 和 Mcl-1。

Anticancer Res. 2022 Mar;42(3):1277-1288. doi: 10.21873/anticanres.15594.

5

Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells.Bcl-x(L)和髓样细胞白血病-1促成结肠癌细胞的凋亡抗性。

World J Gastroenterol. 2008 Jun 28;14(24):3829-40. doi: 10.3748/wjg.14.3829.

6

Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.Noxa的诱导使表达Mcl-1的人结肠癌细胞对小分子Bcl-2/Bcl-xL抑制剂ABT-737敏感。

Clin Cancer Res. 2008 Dec 15;14(24):8132-42. doi: 10.1158/1078-0432.CCR-08-1665.

7

Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer.髓系细胞白血病-1通过抑制细胞凋亡和促进结直肠癌血管生成与肿瘤进展相关。

Am J Cancer Res. 2014 Dec 15;5(1):101-13. eCollection 2015.

8

mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.mTOR 抑制通过抑制 MCL-1，特异性地使 KRAS 或 BRAF 突变的结直肠癌对 BCL-2/BCL-XL 抑制敏感。

Cancer Discov. 2014 Jan;4(1):42-52. doi: 10.1158/2159-8290.CD-13-0315. Epub 2013 Oct 25.

9

Correlation between Mcl-1 and pAKT protein expression in colorectal cancer.结直肠癌中Mcl-1与pAKT蛋白表达的相关性

Int J Clin Exp Pathol. 2010 Oct 12;3(8):768-74.

10

Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes.结直肠癌患者中MCL-1的综合特征：表达、分子谱及预后

Int J Cancer. 2025 Apr 15;156(8):1583-1593. doi: 10.1002/ijc.35304. Epub 2024 Dec 30.

引用本文的文献

1

Cathayanon E induces apoptosis and enhances oxaliplatin sensitivity in colorectal cancer through suppression of MCL1.Cathayanon E通过抑制MCL1诱导结直肠癌细胞凋亡并增强奥沙利铂敏感性。

Apoptosis. 2025 Sep 9. doi: 10.1007/s10495-025-02167-0.