Chen Li-Li, Xu Ke-Wen, Cao Rui-Xue, Shen Guang-Hui, Liu Jin-Rong, Zhou Fan, Li Zhe, Tang Ai-Jie, Liu Pei-Ning
Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Nutrition. 2025 Mar;131:112660. doi: 10.1016/j.nut.2024.112660. Epub 2024 Dec 3.
This study examines the relationship between vitamin K2 (VK2) status and the occurrence of short stature in children.
A cross-sectional analysis was conducted between January 2021 and August 2022, involving 235 children with a clinical diagnosis of short stature at the Second Affiliated Hospital of Wenzhou Medical University (short stature group) and 454 children with average height (±1 SD) from the same period (healthy group). Serum VK2 levels were compared between the two groups. Multivariate logistic regression analysis was used to identify factors associated with short stature, and spearman correlation analysis was used to examine the relationship between VK2 status and age.
Children in the short stature group exhibited lower VK2 levels (P = 0.019) and a significantly higher prevalence of VK2 deficiency (P = 0.011) compared to the healthy group. VK2 deficiency was identified as an independent risk factor for short stature (OR = 1.535, 95% CI = 1.061-2.222, P = 0.023) through multivariate logistic regression analysis. Furthermore, an inverse correlation was observed between serum VK2 levels and age in children aged 2 to 15 years (ρ = -0.133, P < 0.001).
VK2 deficiency may be associated with an increased risk of short stature in children.
本研究探讨维生素K2（VK2）状态与儿童身材矮小发生之间的关系。
于2021年1月至2022年8月进行横断面分析，纳入温州医科大学附属第二医院235例临床诊断为身材矮小的儿童（身材矮小组）以及同期454例身高正常（±1标准差）的儿童（健康组）。比较两组血清VK2水平。采用多因素logistic回归分析确定与身材矮小相关的因素，采用Spearman相关性分析检验VK2状态与年龄之间的关系。
与健康组相比，身材矮小组儿童的VK2水平较低（P = 0.019），VK2缺乏的患病率显著更高（P = 0.011）。通过多因素logistic回归分析，VK2缺乏被确定为身材矮小的独立危险因素（OR = 1.535，95%CI = 1.061 - 2.222，P = 0.023）。此外，在2至15岁儿童中，血清VK2水平与年龄呈负相关（ρ = -0.133，P < 0.001）。
VK2缺乏可能与儿童身材矮小风险增加有关。
