2023年印度与A-24型柯萨奇病毒相关的急性出血性结膜炎疫情

Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023.

作者信息

Chavan Nutan A, Shinde Pooja, Tikute Sanjaykumar, Vishwanathan Rajlakshmi, Deoshatwar Avinash R, Gurav Yogesh K, Waghchaure Rishabh, Ahmed Nishat H, Rani Vannavada S, Khan Vikram, Kelkar Aditya, Jain Harsh H, Jain Amita, Lavania Mallika, Tandale Babasaheb V

机构信息

Enteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India.

Bacteriology Group, ICMR-National Institute of Virology, Sus Road, Pashan, Pune 411021, India.

出版信息

J Infect Public Health. 2025 Feb;18(2):102626. doi: 10.1016/j.jiph.2024.102626. Epub 2024 Dec 17.

DOI:10.1016/j.jiph.2024.102626

PMID:39740338

Abstract

OBJECTIVE

Acute hemorrhagic conjunctivitis (AHC), commonly called pink eye, saw an alarming increase in incidence from July to September 2023 in different parts of India. Pink eye occurrences had reportedly increased three to four times more than in prior years, raising concerns among the community and healthcare professionals. This study aimed to identify the aetiological agent associated with AHC in 2023, genetically characterize the agent and describe the clinical presentation.

METHODS

From July to September 2023, 300 ocular and throat swab samples were collected from patients with AHC across various regions of India, including Maharashtra, Daman & Diu, Delhi, Lucknow, and Hyderabad. These samples represented a diverse geographic spread of the condition. The swabs were examined for qRT-PCR analyses, to detect adenovirus and enterovirus. Following this, conserved regions within the enteroviral 5'-UTR and VP2/3 C gene were further investigated for serotype identification.

RESULTS

Enterovirus was found in 52.6 % (158 out of 300) of the patients. Among the enterovirus-positive samples, coxsackievirus-A24 was present in every positive sample.

CONCLUSION

The rise in AHC cases in India in 2023 was attributed to the Coxsackievirus-A24 strain GIV C5.

摘要

目的

急性出血性结膜炎（AHC），通常称为红眼病，在2023年7月至9月期间，印度不同地区的发病率出现了惊人的增长。据报道，红眼病的发病次数比前几年增加了三到四倍，这引起了社区和医疗保健专业人员的关注。本研究旨在确定2023年与AHC相关的病原体，对该病原体进行基因特征分析并描述其临床表现。

方法

2023年7月至9月期间，从印度各地区（包括马哈拉施特拉邦、达曼和第乌、德里、勒克瑙和海得拉巴）的AHC患者中收集了300份眼拭子和咽拭子样本。这些样本代表了该病在不同地理区域的分布情况。对拭子进行qRT-PCR分析，以检测腺病毒和肠道病毒。在此之后，进一步研究肠道病毒5'-UTR和VP2/3 C基因内的保守区域以进行血清型鉴定。