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心肌细胞特异性Piezo1缺乏通过维持线粒体稳态减轻缺血再灌注损伤。

Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis.

作者信息

Xu Honglin, Chen Xin, Luo Shangfei, Jiang Jintao, Pan Xianmei, He Yu, Deng Bo, Liu Silin, Wan Rentao, Lin Liwen, Tan Qiaorui, Chen Xiaoting, Yao Youfen, He Bin, An Yajuan, Li Jing

机构信息

Innovation Research Center, Shandong University of Traditional Chinese Medicine, Jinan, 250307, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.

Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.

出版信息

Redox Biol. 2025 Feb;79:103471. doi: 10.1016/j.redox.2024.103471. Epub 2024 Dec 27.

DOI:10.1016/j.redox.2024.103471
PMID:39740362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11750285/
Abstract

Ca overload and mitochondrial dysfunction play crucial roles in myocardial ischemia-reperfusion (I/R) injury. Piezo1, a mechanosensitive cation channel, is essential for intracellular Ca homeostasis. The objective of this research was to explore the effects of Piezo1 on mitochondrial function during myocardial I/R injury. We showed that the expression of myocardial Piezo1 was elevated in the infracted area of I/R and cardiomyocyte-specific Piezo1 deficiency (Piezo1) mice attenuated I/R by decreasing infarct size and cardiac dysfunction. Piezo1 regulated mitochondrial fusion and fission to improve mitochondrial function and decrease inflammation and oxidative stress in vivo and in vitro. Mechanistically, myocardial Piezo1 knockout alleviated intracellular calcium overload to normalize calpain-associated mitochondrial homeostasis. Our findings indicated that Piezo1 depletion in cardiomyocytes partially restored mitochondrial homeostasis during cardiac ischemia/reperfusion (I/R) injury. This study suggests an innovative therapeutic strategy to alleviate cardiac I/R injury.

摘要

钙超载和线粒体功能障碍在心肌缺血再灌注（I/R）损伤中起关键作用。Piezo1是一种机械敏感阳离子通道，对细胞内钙稳态至关重要。本研究的目的是探讨Piezo1在心肌I/R损伤期间对线粒体功能的影响。我们发现，I/R梗死区域中心肌Piezo1的表达升高，而心肌细胞特异性Piezo1基因敲除（Piezo1-/-）小鼠通过减小梗死面积和减轻心脏功能障碍减轻了I/R损伤。Piezo1调节线粒体融合与分裂，以改善体内和体外的线粒体功能，并减少炎症和氧化应激。机制上，心肌Piezo1基因敲除减轻了细胞内钙超载，使钙蛋白酶相关的线粒体稳态恢复正常。我们的研究结果表明，心肌细胞中Piezo1的缺失在心脏缺血/再灌注（I/R）损伤期间部分恢复了线粒体稳态。本研究提出了一种减轻心脏I/R损伤的创新治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/f6c5b78b9e2c/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/1e35bffaa3e2/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/f6c5b78b9e2c/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/25a470bbb45e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/f41faeacbb62/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/879d6bca2700/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/db1ddc2cf4f8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/e62a771f8af6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/be6bb8276c5f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/fa51a3676147/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/1e35bffaa3e2/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3afd/11750285/f6c5b78b9e2c/gr9.jpg

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本文引用的文献

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2
FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.FBXL4 通过 Drp1 介导的线粒体动力学和下游 SERCA2a 的调节来保护 HFpEF。
Redox Biol. 2024 Apr;70:103081. doi: 10.1016/j.redox.2024.103081. Epub 2024 Feb 9.
3
Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation.
压电式力传感器与心脏
Cold Spring Harb Perspect Biol. 2025 Jul 28. doi: 10.1101/cshperspect.a041806.
高血糖触发 RyR2 依赖性改变线粒体钙动态平衡以应对心脏缺血再灌注：DRP1 激活的关键作用。
Redox Biol. 2024 Apr;70:103044. doi: 10.1016/j.redox.2024.103044. Epub 2024 Jan 19.
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Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential.心肌缺血/再灌注损伤中的炎症：潜在机制与治疗潜力
Antioxidants (Basel). 2023 Oct 31;12(11):1944. doi: 10.3390/antiox12111944.
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