Ishide N, Maruyama Y, Isoyama S, Nishioka O, Takishima T
Jpn Circ J. 1985 Feb;49(2):215-23. doi: 10.1253/jcj.49.215.
In order to evaluate how pressure and flow at the outlet of a ventricle are determined by the interaction between the ventricle and an aortic input impedance, we examined the effects of independent changes in the peripheral resistance and in the aortic compliance using isolated canine left ventricle preparations. There was an inverse linear relationship of mean values between pressure and cardiac output under pure resistance changes when coronary flow was maintained constant. But, when the coronary perfusion pressure depended on mean aortic pressure, the relationship was no longer linear under a critical aortic pressure. When aortic compliance was increased, late systolic flow was enhanced and late systolic pressure decreased such that the stroke volume increased. The top part of the pressure-volume loop showed a configurational change from the right side down to the left side down. Changes in pressure and flow wave forms, and in the pressure-volume loop can be predicted by an electrical model in which time varying capacitance arranged in series with the internal resistance was used as a ventricular model.
为了评估心室出口处的压力和流量是如何由心室与主动脉输入阻抗之间的相互作用所决定的，我们使用离体犬左心室标本研究了外周阻力和主动脉顺应性独立变化的影响。当冠状动脉流量保持恒定时，在纯阻力变化下，压力与心输出量的平均值呈负线性关系。但是，当冠状动脉灌注压力取决于平均主动脉压力时，在临界主动脉压力下该关系不再呈线性。当主动脉顺应性增加时，收缩晚期流量增加，收缩晚期压力降低，从而使搏出量增加。压力-容积环的顶部显示出从右侧向下到左侧向下的构型变化。压力和流量波形以及压力-容积环的变化可以通过一个电学模型来预测，在该模型中，将与内阻串联的时变电容用作心室模型。
