Kirlić Namik, Lennard-Jones Molly, Atli Merve, Malievskaia Ekaterina, Modlin Nadav L, Peck Stephanie Knatz, Gaillard Alice, Goodwin Guy M, Koelpin Don
Compass Pathways, London (Kirlić, Lennard-Jones, Atli, Malievskaia, Gaillard, Goodwin, Koelpin); Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Modlin); School of Medicine, University of California San Diego, San Diego (Peck).
Am J Psychiatry. 2025 Jan 1;182(1):126-132. doi: 10.1176/appi.ajp.20230884.
The psychedelic experience can be challenging. There is a need for a structured framework for providing psychological support to individuals with mental health conditions receiving investigational psilocybin treatment. The primary benefit of such a framework is to support a safe and meaningful psilocybin experience. It also enables future research on the facets of psychological support and/or psychotherapy that most optimally complement psilocybin treatment. The authors describe the Compass Psychological Support Model (CPSM), currently used to support participants with treatment-resistant depression in Compass-sponsored clinical trials of investigational COMP360 psilocybin treatment. The authors also outline the therapist training, mentoring, and fidelity assessment programs they have developed to ensure the quality and consistency of the CPSM delivery.
迷幻体验可能具有挑战性。对于接受试验性裸盖菇素治疗的心理健康状况患者，需要一个结构化框架来提供心理支持。这样一个框架的主要好处是支持安全且有意义的裸盖菇素体验。它还能使未来对最能优化补充裸盖菇素治疗的心理支持和/或心理治疗方面进行研究。作者描述了指南针心理支持模型（CPSM），该模型目前用于在指南针赞助的试验性COMP360裸盖菇素治疗的临床试验中支持难治性抑郁症患者。作者还概述了他们为确保CPSM实施的质量和一致性而制定的治疗师培训、指导和保真度评估计划。
