迈向可翻译的致幻剂诱导神经可塑性生物标志物
Toward Translatable Biomarkers of Psychedelic-Induced Neuroplasticity.
作者信息
Olson David E
机构信息
Institute for Psychedelics and Neurotherapeutics, Department of Chemistry, Department of Biochemistry & Molecular Medicine, Center for Neuroscience, University of California, Davis, Davis, Calif.
出版信息
Am J Psychiatry. 2025 Jan 1;182(1):10-12. doi: 10.1176/appi.ajp.20231054.
Abstract
Numerous preclinical studies have demonstrated that psychedelics promote the growth of cortical neurons in the prefrontal cortex. However, measuring psychedelic-induced structural plasticity in humans has remained a challenge. New advances in positron emission tomography imaging could facilitate the measurement of synaptic proteins in humans following psychedelic administration. Identifying a translatable biomarker of psychedelic-induced neuroplasticity would enable patient stratification and determination of optimal dosing paradigms while also facilitating the discovery of novel compounds that produce similar effects on structural neuroplasticity.
摘要
众多临床前研究表明，迷幻剂可促进前额叶皮质中皮质神经元的生长。然而，测量人类中迷幻剂诱导的结构可塑性仍然是一项挑战。正电子发射断层扫描成像技术的新进展可能有助于在给予迷幻剂后测量人类的突触蛋白。确定迷幻剂诱导的神经可塑性的可转化生物标志物将能够进行患者分层并确定最佳给药方案，同时还有助于发现对结构神经可塑性产生类似影响的新型化合物。
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