Wang Yaobin, Zhao Xinghua, Zhang Xiangyu, Yang Yuhua, Zhang Weikang, Liu Shaocheng, Liu Zhenlei, Zhang Lei, Wang Kai, Wu Hao
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Front Surg. 2024 Dec 16;11:1482821. doi: 10.3389/fsurg.2024.1482821. eCollection 2024.
Low back pain (LBP) is a widespread clinical symptom affecting nearly all age groups and is a leading cause of disability worldwide. Degenerative changes in the spine and paraspinal tissues primarily contribute to the etiology of LBP.
We conducted this systematic review of animal models of paraspinal muscle (PSM) degeneration secondary to degenerative intervertebral disc (IVD), providing a comprehensive evaluation of PSM structural changes observed in these models at both macroscopic and microscopic levels.
PubMed, EMBASE, Web of Science, Cochrane Library, and MEDLINE Ovid databases were searched through November 2023. Literature was sequentially screened based on titles, abstracts, inclusion of animal models and full texts. A manual search of reference lists from all eligible studies was also performed to identify any eligible article. Two independent reviewers screened the articles according to inclusion and exclusion criteria. The risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation's Risk of Bias tool.
A total of nine studies were included in the final analysis after a comprehensive screening process. The included studies were assessed for various aspects of the multifidus muscle. Given the limited number of studies and the substantial heterogeneity among them, a quantitative meta-analysis was deemed inappropriate.
This systematic review shows a comprehensive analysis of structural changes in the multifidus muscle in animal models of IVD degeneration and offers crucial insights for developing improved rodent models of IVD degeneration and assessing a battery of approaches for multifidus degeneration.
腰痛（LBP）是一种广泛存在的临床症状，几乎影响所有年龄组，是全球致残的主要原因。脊柱和椎旁组织的退行性改变是腰痛病因的主要因素。
我们对椎间盘退变继发的椎旁肌（PSM）退变的动物模型进行了系统评价，从宏观和微观层面全面评估了这些模型中观察到的PSM结构变化。
检索了截至2023年11月的PubMed、EMBASE、Web of Science、Cochrane图书馆和MEDLINE Ovid数据库。根据标题、摘要、动物模型的纳入情况和全文对文献进行了顺序筛选。还对所有符合条件的研究的参考文献列表进行了人工检索，以确定任何符合条件的文章。两名独立的评审员根据纳入和排除标准对文章进行筛选。使用实验室动物实验系统评价中心的偏倚风险工具评估偏倚风险。
经过全面筛选过程，最终分析共纳入9项研究。对纳入研究的多裂肌的各个方面进行了评估。鉴于研究数量有限且研究之间存在很大异质性，认为进行定量荟萃分析不合适。
本系统评价全面分析了椎间盘退变动物模型中多裂肌的结构变化，为开发改进的椎间盘退变啮齿动物模型和评估一系列多裂肌退变方法提供了关键见解。
