一项针对癌症诊断后1.5年有性问题的年轻成年人的网络心理教育干预措施的效果——一项随机对照试验的结果。
Efficacy of a web-based psychoeducational intervention targeting young adults with sexual problems 1.5 years after cancer diagnosis-Results from a randomized controlled trial.
作者信息
Bergström Charlotta, Skog Rebecca, Eriksson Lars E, Lampic Claudia, Wettergren Lena
机构信息
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Department of Surgery and Urology, Danderyd Hospital, Stockholm, Sweden.
出版信息
Digit Health. 2024 Dec 26;10:20552076241310037. doi: 10.1177/20552076241310037. eCollection 2024 Jan-Dec.
OBJECTIVE
To test the efficacy of a web-based psychoeducational intervention, Fex-Can Sex, in reducing sexual dysfunction in young adults with cancer.
METHODS
This randomized controlled trial evaluated a 12-week web-based self-help intervention. Young adults aged 19-40 who reported sexual dysfunction 1.5 years after cancer diagnosis were drawn from a population-based cohort. Participants were randomized to an intervention group (IG, = 72) or a control group (CG, = 66) that solely received standard care. Primary outcome was assessed by a domain of the Patient Reported Outcome Measures Information Systems SexFS: "Satisfaction with sex life." Secondary outcomes included additional SexFS domains, body image (BIS), emotional distress (HADS), health-related quality of life (EORTC QLQ-C30), and self-efficacy related to sex. Surveys were completed at baseline, post-intervention, and three months later. Effects of the intervention were tested with -tests, and linear mixed models (LMMs), including intention-to-treat and subgroup analyses. Additionally, the IG was asked about their experiences of the program with study-specific questions.
RESULTS
There were no differences in primary or secondary outcomes between the IG and the CG at post-intervention. Subgroup analyses showed that individuals with greater sexual problems at baseline improved over time, regardless of group allocation. Participants spent a mean time of 20.7 min on the program. The study-specific items showed that the majority of participants in the IG appreciated the program and would recommend it to others.
CONCLUSION
The Fex-Can Sex intervention did not show effect on primary and secondary outcomes. Adherence to the intervention was low, and future interventions are recommended to include more interactive components to enhance usage.
CLINICAL TRIAL REGISTRATION
The trial was registered on 25 January, 2016 (trial number: 36621459).
目的
测试基于网络的心理教育干预措施“Fex-Can Sex”在降低癌症青年患者性功能障碍方面的疗效。
方法
这项随机对照试验评估了一项为期12周的基于网络的自助干预措施。从一个基于人群的队列中选取了19至40岁、在癌症诊断后1.5年报告存在性功能障碍的青年成年人。参与者被随机分为干预组（IG，n = 72）或仅接受标准护理的对照组（CG，n = 66）。主要结局通过患者报告结局测量信息系统性健康领域（SexFS）的一个维度“对性生活的满意度”进行评估。次要结局包括SexFS的其他维度、身体意象（BIS）、情绪困扰（HADS）、健康相关生活质量（EORTC QLQ-C30）以及与性相关的自我效能感。在基线、干预后和三个月后完成调查。采用t检验和线性混合模型（LMMs）对干预效果进行测试，包括意向性分析和亚组分析。此外，向干预组询问他们对该项目的体验，并提出特定于研究的问题。
结果
干预后，干预组和对照组在主要或次要结局方面没有差异。亚组分析表明，无论分组如何，基线时性问题较多的个体随时间推移有所改善。参与者在该项目上平均花费20.7分钟。特定于研究的项目显示，干预组的大多数参与者对该项目表示赞赏，并会向他人推荐。
结论
“Fex-Can Sex”干预措施在主要和次要结局方面未显示出效果。干预的依从性较低，建议未来的干预措施纳入更多互动成分以提高使用率。
临床试验注册
该试验于2016年1月25日注册（试验编号：36621459）。
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