Zhou Jia-Bin, Wei Tian-Peng, Wu Dan, Zhou Feng, Wang Ru-Xing
Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University, Wuxi 214023, China.
Cardiovasc Ther. 2024 Dec 13;2024:6615720. doi: 10.1155/cdr/6615720. eCollection 2024.
Ischemic heart disease (IHD) remains one of the most prominent causes of mortality and morbidity globally, and the risk of ischemia-reperfusion injury is becoming more severe and constant. This underscores the need to develop new methods to protect the heart from damage. DJ-1 is a multifunctional intracellular protein encoded by the gene that plays roles in processes including the control of autophagy, the preservation of mitochondrial integrity, the prevention of apoptosis, and the elimination of oxidative stress. DJ-1 has recently been the focus of growing interest as a target molecule relevant to treating myocardial ischemia-reperfusion injury due to its protective properties and its role in cellular response mechanisms. Consistently, DJ-1-related interventions, such as its exogenous administration or the use of pharmacological agents, have been demonstrated to help protect the myocardium from ischemia-reperfusion injury and associated adverse outcomes. This review provides an overview of DJ-1 and its therapeutic relevance in the myocardium in the setting of ischemia and reperfusion.
缺血性心脏病（IHD）仍然是全球范围内导致死亡和发病的最主要原因之一，并且缺血再灌注损伤的风险正变得愈发严重且持续存在。这凸显了开发新方法以保护心脏免受损伤的必要性。DJ-1是一种由该基因编码的多功能细胞内蛋白质，它在包括自噬控制、线粒体完整性维持、细胞凋亡预防以及氧化应激消除等过程中发挥作用。由于其保护特性及其在细胞反应机制中的作用，DJ-1最近作为与治疗心肌缺血再灌注损伤相关的靶分子受到越来越多的关注。一致地，与DJ-1相关的干预措施，如外源性给予或使用药物制剂，已被证明有助于保护心肌免受缺血再灌注损伤及相关不良后果。本综述概述了DJ-1及其在缺血和再灌注情况下对心肌的治疗相关性。
