Wang Xiaoxu, Wu Lingjun, Liu Jing, Ma Cong, Liu Juan, Zhang Qin
Rheumatology Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital, Beijing 101300, China.
Biomed Pharmacother. 2025 Jan;182:117802. doi: 10.1016/j.biopha.2024.117802. Epub 2024 Dec 31.
Patients suffering from psoriatic arthritis (PsA) often experience depression due to chronic joint pain, which significantly hinders their recovery process. However, the relationship between these two conditions is not well understood. Through a review of existing studies, we revealed that certain neuroendocrine hormones and neurotransmitters are involved in the neuroimmune interactions related to both PsA and depression. These include adrenocorticotropin-releasing hormone (CRH), adrenocorticotropin (ACTH), cortisol, monoamine neurotransmitters, and brain-derived neurotrophic factor (BDNF). Notably, the signalling pathway involving CRH, MCs, and Th17 cells plays a crucial role in linking PsA with depression; thus, this pathway may help clarify their connection. In this review, we outline the inflammatory immune changes associated with PsA and depression. Additionally, we explore how neuroendocrine hormones and neurotransmitters influence inflammatory responses in these two conditions. Finally, our focus will be on potential treatment strategies for patients with PsA and depression through the targeting of the CRH-MC-Th17 pathway. This review aims to provide a theoretical framework as well as new therapeutic targets for managing PsA alongside depression.
银屑病关节炎（PsA）患者常因慢性关节疼痛而出现抑郁，这严重阻碍了他们的康复进程。然而，这两种病症之间的关系尚未得到充分理解。通过对现有研究的综述，我们发现某些神经内分泌激素和神经递质参与了与PsA和抑郁相关的神经免疫相互作用。这些包括促肾上腺皮质激素释放激素（CRH）、促肾上腺皮质激素（ACTH）、皮质醇、单胺神经递质和脑源性神经营养因子（BDNF）。值得注意的是，涉及CRH、肥大细胞（MCs）和辅助性T细胞17（Th17）细胞的信号通路在将PsA与抑郁联系起来方面起着关键作用；因此，该通路可能有助于阐明它们之间的联系。在本综述中，我们概述了与PsA和抑郁相关的炎症免疫变化。此外，我们探讨了神经内分泌激素和神经递质如何影响这两种病症中的炎症反应。最后，我们将重点关注通过靶向CRH-MC-Th17通路为PsA和抑郁患者提供潜在的治疗策略。本综述旨在为同时管理PsA和抑郁提供一个理论框架以及新的治疗靶点。
