Maslansky C J, Williams G M
Mech Ageing Dev. 1985 Feb;29(2):191-203. doi: 10.1016/0047-6374(85)90018-1.
The DNA repair capabilities of cultured hepatocytes derived from five mammalian species in response to a broad range of ultraviolet light exposures were measured. Differences in the induction of DNA repair synthesis and the proportion of responding cells were noted only for the lowest fluences. These differences appeared to be positively correlated with the potential lifespans of the species involved; mouse and rat hepatocytes displayed less repair than those from guinea pig or rabbit. At higher fluence levels, however, there were no differences in the amount of repair induced. Thus the maximal repair potential of hepatocytes derived from the rat, mouse, hamster, guinea pig and rabbit were the same.
测定了来自五种哺乳动物的培养肝细胞在受到广泛紫外线照射后的DNA修复能力。仅在最低光通量下，才观察到DNA修复合成诱导以及应答细胞比例方面的差异。这些差异似乎与相关物种的潜在寿命呈正相关；小鼠和大鼠的肝细胞显示出的修复能力低于豚鼠或兔子的肝细胞。然而，在较高光通量水平下，诱导的修复量没有差异。因此，大鼠、小鼠、仓鼠、豚鼠和兔子的肝细胞的最大修复潜力是相同的。
