Kng Jia Hao, Luo Lizhu, Choy Olivia, Yu Junhong
Psychology, School of Social Sciences, Nanyang Technological University, Singapore.
Psychology, School of Social Sciences, Nanyang Technological University, Singapore.
Biol Psychol. 2025 Jan;194:108979. doi: 10.1016/j.biopsycho.2024.108979. Epub 2024 Dec 30.
Previous research has found functional connectivity in various networks to be altered in psychopathy and has theorised a link between these networks and the self-control-related deficits observed in psychopathy. However, this theory has yet to be tested adequately and empirically. The present study investigated the association between psychopathy, self-control, and intrinsic functional connectivity in 179 healthy adults from the MPI Leipzig Mind Brain Body dataset. Participants completed an affective switching task and questionnaires relating to psychopathy and self-control and underwent resting-state fMRI scans. Functional connectivity matrices were extracted for each subject, and network-based statistics was used to identify intrinsic resting-state functional networks associated with psychopathy scores. Significant networks that are positively and negatively associated with psychopathy emerged in the analyses. The functional connections that correlated positively with psychopathy was mostly characterised by strong connections between the default mode network and salience network, while the functional connections negatively correlated with psychopathy was largely characterised by strong within-dorsal attention network connectivity. Both the psychopathy-associated positive and negative networks were significantly correlated with measures of self-control and impulsivity. Furthermore, the negative network mediated the relationship between psychopathy and affective task-switching. Findings suggest that alterations in intrinsic functional connectivity are significantly implicated in psychopathy; these alterations possibly account for some self-control related deficits observed in psychopathy.
先前的研究发现，精神病态患者的各种网络中的功能连接发生了改变，并提出了这些网络与在精神病态中观察到的自我控制相关缺陷之间的联系。然而，这一理论尚未得到充分的实证检验。本研究调查了来自马克斯·普朗克学会莱比锡心智脑体数据集的179名健康成年人中精神病态、自我控制和内在功能连接之间的关联。参与者完成了一项情感转换任务以及与精神病态和自我控制相关的问卷，并接受了静息态功能磁共振成像扫描。为每个受试者提取功能连接矩阵，并使用基于网络的统计方法来识别与精神病态得分相关的内在静息态功能网络。分析中出现了与精神病态呈正相关和负相关的显著网络。与精神病态呈正相关的功能连接主要表现为默认模式网络和突显网络之间的强连接，而与精神病态呈负相关的功能连接主要表现为背侧注意网络内的强连接。与精神病态相关的正性和负性网络均与自我控制和冲动性测量显著相关。此外，负性网络介导了精神病态与情感任务转换之间的关系。研究结果表明，内在功能连接的改变在精神病态中具有重要意义；这些改变可能解释了在精神病态中观察到的一些与自我控制相关的缺陷。
