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一名严重硫酸铜中毒患者成功治疗后出现的残余高血糖症。

Residual hyperglycemia after successful treatment of a patient with severe copper sulfate poisoning.

作者信息

Li Ting, Lu Yuan-Qiang

机构信息

Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Zhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, Hangzhou 310003, China.

出版信息

J Zhejiang Univ Sci B. 2024 Dec 18;25(12):1120-1124. doi: 10.1631/jzus.B2400305.

Abstract

Copper sulfate is a frequently used copper compound in laboratory settings, with instances of poisoning being uncommon. A study conducted by the American Association of Poison Control Centers' National Poison Data System found that only 140 individuals were exposed to copper compounds over the course of a year, with five cases being intentional (Gummin et al., 2023). Severe poisoning from copper sulfate can result in isolated gastrointestinal injury (Galust et al., 2023), intravascular hemolysis (Adline et al., 2024), rhabdomyolysis (Richards et al., 2020), and other symptoms documented in the literature. However, there have been no reports of long-term uncontrolled hyperglycemia in patients with copper sulfate poisoning. This case study documents the treatment approach for a patient with unexplained, long-term, uncontrolled hyperglycemia, alongside multiple organ dysfunction resulting from intentional ingestion of a large dose of copper sulfate. This case report details the long-term complications in a patient's recovery from acute copper sulfate, highlighting the significance of ongoing monitoring and intervention.

摘要

硫酸铜是实验室环境中常用的铜化合物,中毒情况并不常见。美国毒物控制中心协会国家毒物数据系统进行的一项研究发现,一年中仅有140人接触过铜化合物,其中5例为故意接触(古明等人,2023年)。硫酸铜严重中毒可导致孤立性胃肠道损伤(加卢斯特等人,2023年)、血管内溶血(阿德琳等人,2024年)、横纹肌溶解(理查兹等人,2020年)以及文献中记载的其他症状。然而,尚无硫酸铜中毒患者出现长期未控制的高血糖症的报告。本病例研究记录了一名患有无法解释的长期未控制高血糖症患者的治疗方法,以及因故意大量摄入硫酸铜导致的多器官功能障碍。本病例报告详细介绍了患者从急性硫酸铜中毒中康复后的长期并发症,强调了持续监测和干预的重要性。

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本文引用的文献

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"Campfire corrosive: Isolated gastrointestinal injury following ingestion of copper salts".
Am J Emerg Med. 2023 Aug;70:210.e5-210.e8. doi: 10.1016/j.ajem.2023.05.021. Epub 2023 May 19.

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