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本文引用的文献

1
Local anesthetic systemic toxicity: awareness, recognition, and risk mitigation in the emergency department.局部麻醉药全身毒性：急诊科的认识、识别及风险缓解
Clin Exp Emerg Med. 2024 Jun;11(2):121-126. doi: 10.15441/ceem.24.231. Epub 2024 May 23.
2
Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review.脂质乳剂复苏在药物毒性中的作用机制：叙述性综述。
Korean J Anesthesiol. 2023 Jun;76(3):171-182. doi: 10.4097/kja.23031. Epub 2023 Jan 26.
3
Anesthetic management of patients with carnitine deficiency or a defect of the fatty acid β-oxidation pathway: A narrative review.肉碱缺乏或脂肪酸β-氧化途径缺陷患者的麻醉管理：叙述性综述。
Medicine (Baltimore). 2022 Feb 18;101(7):e28853. doi: 10.1097/MD.0000000000028853.
4
Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts.脂质乳剂可减轻毒性局部麻醉药在大鼠心肌细胞中诱导的肉毒碱酰基辅酶 A 转移酶抑制作用。
Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065978. doi: 10.1177/09603271211065978.
5
Bupivacaine-induced contraction is attenuated by endothelial nitric oxide release modulated by activation of both stimulatory and inhibitory phosphorylation (Ser1177 and Thr495) of endothelial nitric oxide synthase.布比卡因诱导的收缩通过内皮型一氧化氮合酶的刺激和抑制磷酸化（Ser1177 和 Thr495）调节的内皮型一氧化氮释放而减弱。
Eur J Pharmacol. 2019 Jun 15;853:121-128. doi: 10.1016/j.ejphar.2019.03.026. Epub 2019 Mar 15.
6
Lipid emulsion reverses bupivacaine-induced apoptosis of h9c2 cardiomyocytes: PI3K/Akt/GSK-3β signaling pathway.脂肪乳剂逆转布比卡因诱导的 h9c2 心肌细胞凋亡：PI3K/Akt/GSK-3β 信号通路。
Environ Toxicol Pharmacol. 2016 Mar;42:85-91. doi: 10.1016/j.etap.2016.01.004. Epub 2016 Jan 9.
7
Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta.脂质乳剂减弱离体大鼠主动脉中乙酰胆碱诱导的舒张作用。
Biomed Res Int. 2015;2015:871545. doi: 10.1155/2015/871545. Epub 2015 Jul 27.
8
Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by Intralipid®.L-NAME对一氧化氮合酶的全身阻断会增加左心室收缩压，而脂质乳剂（Intralipid®）不会使其进一步升高。
Int J Biol Sci. 2014 Mar 18;10(4):367-76. doi: 10.7150/ijbs.8048. eCollection 2014.
9
Ropivacaine-induced contraction is attenuated by both endothelial nitric oxide and voltage-dependent potassium channels in isolated rat aortae.罗哌卡因诱导的收缩在分离的大鼠主动脉中被内皮一氧化氮和电压依赖性钾通道所抑制。
Biomed Res Int. 2013;2013:565271. doi: 10.1155/2013/565271. Epub 2013 Nov 20.
10
Effect of two lipid emulsions on reversing high-dose levobupivacaine-induced reduced vasoconstriction in the rat aortas.两种脂肪乳剂对逆转高剂量左布比卡因致大鼠主动脉收缩减弱的影响。
Cardiovasc Toxicol. 2013 Dec;13(4):370-80. doi: 10.1007/s12012-013-9218-y.

Direct effect of lipid emulsion treatment on local anesthetic systemic toxicity.

作者信息

Sohn Ju-Tae

机构信息

Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.

Institute of Medical Science, Gyeongsang National University, Jinju, Korea.

出版信息

Clin Exp Emerg Med. 2024 Dec;11(4):399-401. doi: 10.15441/ceem.24.326. Epub 2024 Dec 24.

DOI:10.15441/ceem.24.326
PMID:39743309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11700683/
Abstract
摘要