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一名患有因子V莱顿突变和高因子VIII水平的患者出现左心室血栓伴无症状心肌梗死：病例报告

Left Ventricular Thrombus With Silent Myocardial Infarction in a Patient With Factor V Leiden Mutation and High Factor VIII Levels: A Case Report.

作者信息

Zahid Abdul Samad, Shariff Mohammed, Huggett Robert

机构信息

Cardiology, Russells Hall Hospital, Dudley, GBR.

出版信息

Cureus. 2024 Dec 2;16(12):e74944. doi: 10.7759/cureus.74944. eCollection 2024 Dec.

DOI:10.7759/cureus.74944
PMID:39744300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11693404/
Abstract

Silent myocardial infarction (SMI) is a type of myocardial infarction that occurs in the absence of, or with, minimal symptoms, often leading to a delay in medical treatment. There is a lack of data regarding the incidence and/or prevalence of a left ventricular (LV) thrombus in those who have had an SMI, due to the rarity of such cases. We describe a case of an SMI with LV thrombus in an otherwise healthy young man, whose first presentation was with stroke-type symptoms and who was also later found to have a Factor V Leiden (FVL) mutation and raised factor VIII levels. Further research is needed to investigate the relationship between these haematological conditions and the risk of arterial thrombosis including stroke, SMI, and LV thrombus.

摘要

无症状性心肌梗死（SMI）是一种在无明显症状或仅有轻微症状的情况下发生的心肌梗死，常常导致治疗延误。由于此类病例罕见，关于发生过SMI的患者左心室（LV）血栓形成的发病率和/或患病率的数据匮乏。我们描述了一例在其他方面健康的年轻男性发生的伴有LV血栓的SMI病例，其首次表现为中风样症状，后来还发现其存在因子V莱顿（FVL）突变且因子VIII水平升高。需要进一步研究来调查这些血液学状况与包括中风、SMI和LV血栓在内的动脉血栓形成风险之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/db6338422ec4/cureus-0016-00000074944-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/4c8b8c6c8fad/cureus-0016-00000074944-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/855fd3c7614a/cureus-0016-00000074944-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/32c105d48cb1/cureus-0016-00000074944-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/ee3cd60da337/cureus-0016-00000074944-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/db6338422ec4/cureus-0016-00000074944-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/4c8b8c6c8fad/cureus-0016-00000074944-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/855fd3c7614a/cureus-0016-00000074944-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/32c105d48cb1/cureus-0016-00000074944-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/ee3cd60da337/cureus-0016-00000074944-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3e/11693404/db6338422ec4/cureus-0016-00000074944-i05.jpg

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本文引用的文献

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A Literature Review of Cannabis and Myocardial Infarction-What Clinicians May Not Be Aware Of.
大麻与心肌梗死的文献综述——临床医生可能不知道的事
CJC Open. 2020 Sep 3;3(1):12-21. doi: 10.1016/j.cjco.2020.09.001. eCollection 2021 Jan.
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Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis.家族中FVIII:C水平升高与静脉和动脉血栓形成风险增加相关。
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