Ye Kui, Cao Huaxiang, Xu Zihao, Liu Peng, Jiang Xueying, Liu Qiancheng, Yang Hongquan, Huo Menghua, Wang Teng, Wang Jian
Department of Gastroenterology, Wuxi Second Geriatric Hospital, Wuxi Huishan Second People's Hospital, Wuxi, 214174, Jiangsu, China.
Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi, 214122, Jiangsu, China.
J Cancer. 2025 Jan 1;16(1):81-91. doi: 10.7150/jca.102204. eCollection 2025.
Colorectal carcinoma (CRC) is a highly prevalent and life-threatening disease with multi-stage progression, characterized by diverse molecular expression patterns at distinct stages, making treatment particularly challenging. Early detection and diagnosis of CRC are vital and can greatly benefit from the discovery of effective biomarkers. Researchers have identified novel gene signatures that play pivotal roles in specific CRC types or stages. Leucine Zipper Tumor Suppressor Family Member 3 (LZTS3), a well-known tumor suppressor in several cancer types such as lung carcinoma, has sparked interest. However, our comprehensive studies revealed a contrasting role for LZTS3 in CRC. We found that LZTS3 was highly expressed in CRC cases and associated with poor clinical outcomes. Gene enrichment analyses indicated that LZTS3 expression levels correlate with immune checkpoint inhibition, emphasizing the therapeutic potential of LZTS3 for colorectal adenocarcinoma (COAD). In conclusion, our results suggest a potential oncogenic role of LZTS3 in colorectal cancers, challenging previous perceptions of its function. Further research is needed to explore the precise mechanisms underlying this unexpected role and its implications for CRC diagnosis and therapy.
结直肠癌（CRC）是一种高度常见且危及生命的疾病，具有多阶段进展特征，在不同阶段表现出多样的分子表达模式，这使得治疗极具挑战性。CRC的早期检测和诊断至关重要，而发现有效的生物标志物能带来极大益处。研究人员已鉴定出在特定CRC类型或阶段起关键作用的新型基因特征。亮氨酸拉链肿瘤抑制因子家族成员3（LZTS3），在肺癌等多种癌症类型中是著名的肿瘤抑制因子，已引发关注。然而，我们的全面研究揭示了LZTS3在CRC中具有相反的作用。我们发现LZTS3在CRC病例中高表达，且与不良临床结果相关。基因富集分析表明，LZTS3表达水平与免疫检查点抑制相关，这凸显了LZTS3在结肠腺癌（COAD）中的治疗潜力。总之，我们的结果提示LZTS3在结直肠癌中具有潜在的致癌作用，挑战了以往对其功能的认知。需要进一步研究来探索这一意外作用背后的精确机制及其对CRC诊断和治疗的影响。
