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作为一种新的预后因素，受益气化瘀解毒汤调控于结直肠癌中。

as a novel prognostic factor is regulated by Yiqi Huayu Jiedu Decoction in colorectal cancer.

作者信息

Zhu Yejin, Wang Xinping, Wang Qianyi, Shi Shanfan, He Jun, Jiang Chao

机构信息

School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.

出版信息

J Cancer. 2025 Jan 1;16(1):351-367. doi: 10.7150/jca.99278. eCollection 2025.

DOI:10.7150/jca.99278
PMID:39744582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11660119/
Abstract

We studied the prognostic value of in colorectal cancer (CRC) using bioinformatics. exhibited differential expression between the tumor and control samples, and improved survival was observed in patients with increased expression. The univariate and multivariate analyses confirmed as an independent prognostic factor for CRC, based on which a nomogram was constructed for predicting survival in patients with CRC. Additionally, higher expression was correlated with increased immunological/stromal/ESTIMATE scores as well as immune cell infiltration and was strongly and positively associated with T helper cells and macrophages. Furthermore, significant positive correlations were observed between SIGLEC1 expression and inhibitory/coinhibitory immunological genes. Additionally, the TIDE results of patients with CRC showed that increased expression was related to poorer immunotherapeutic responses. In clinical samples from patients with CRC, a decrease in expression was noted compared to para-cancerous tissues and samples from patients who received Yiqi Huayu Jiedu Decoction (YHJD) treatment. The results indicated the superior efficacy of YHJD against CRC in inhibiting tumor metastasis. Our study demonstrates that SIGLEC1 serves as a prognostic factor for CRC, strongly linked to immune response, and can be modulated by YHJD, suggesting novel avenues for CRC treatment.

摘要

我们使用生物信息学研究了[具体指标]在结直肠癌（CRC）中的预后价值。[具体指标]在肿瘤样本和对照样本之间表现出差异表达，并且在[具体指标]表达增加的患者中观察到生存期延长。单变量和多变量分析证实[具体指标]是CRC的独立预后因素，并据此构建了一个列线图来预测CRC患者的生存期。此外，较高的[具体指标]表达与免疫/基质/ESTIMATE评分增加以及免疫细胞浸润相关，并且与辅助性T细胞和巨噬细胞呈强正相关。此外，在SIGLEC1表达与抑制性/共抑制性免疫基因之间观察到显著的正相关。此外，CRC患者的TIDE结果表明，[具体指标]表达增加与较差的免疫治疗反应相关。在CRC患者的临床样本中，与癌旁组织和接受益气化瘀解毒汤（YHJD）治疗患者的样本相比，[具体指标]表达降低。[具体指标]结果表明YHJD在抑制肿瘤转移方面对CRC具有卓越疗效。我们的研究表明，SIGLEC1作为CRC的一个预后因素，与免疫反应密切相关，并且可以被YHJD调节，这为CRC治疗提供了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/416bf3919616/jcav16p0351g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/c04ff08a397c/jcav16p0351g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/cf8d42e177ec/jcav16p0351g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/1fc8384f07f5/jcav16p0351g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/c83c2a49718c/jcav16p0351g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/416bf3919616/jcav16p0351g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/c04ff08a397c/jcav16p0351g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/3fa8537d094a/jcav16p0351g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/6ee5b8995c87/jcav16p0351g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/f0e473ccfd00/jcav16p0351g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/cf8d42e177ec/jcav16p0351g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/1fc8384f07f5/jcav16p0351g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/c83c2a49718c/jcav16p0351g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f7/11660119/416bf3919616/jcav16p0351g008.jpg

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本文引用的文献

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Yiqi Huayu Jiedu Decoction inhibits liver metastasis of colorectal cancer via enhancing natural killer cells function.益气化瘀解毒汤通过增强自然杀伤细胞功能抑制结直肠癌肝转移。
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