Metelmann Soeren, Thompson Alexander, Donten Anna, Oke Segun, Sun Suzy, Borrow Ray, Xu Feng, Vivancos Roberto, Decraene Valerie, Pellis Lorenzo, Hall Ian
Field Service, UK Health Security Agency, Liverpool, United Kingdom.
School of Health Sciences, Manchester University, Manchester, United Kingdom.
PLoS One. 2025 Jan 2;20(1):e0316184. doi: 10.1371/journal.pone.0316184. eCollection 2025.
The genus Neisseria includes two major human pathogens: N. meningitidis causing bacterial meningitis/septicemia and N. gonorrhoeae causing gonorrhoea. Mathematical models have been used to simulate their transmission and control strategies, and the recent observation of a meningococcal B (MenB) vaccine being partially effective against gonorrhoea has led to an increased modeling interest. Here we conducted a systematic review of the literature, focusing on studies that model vaccination strategies with MenB vaccines against Neisseria incidence and antimicrobial resistance. Using journal, preprint, and grey literature repositories, we identified 52 studies that we reviewed for validity, model approaches and assumptions. Most studies showed a good quality of evidence, and the variety of approaches along with their different modeling angles, was assuring especially for gonorrhoea studies. We identified options for future research, including the combination of both meningococcal and gonococcal infections in studies to have better estimates for vaccine benefits, and the spill over of gonorrhoea infections from the heterosexual to the MSM community and vice versa. Cost-effectiveness studies looking at at-risk and the wider populations can then be used to inform vaccine policies on gonorrhoea, as they have for meningococcal disease.
引起细菌性脑膜炎/败血症的脑膜炎奈瑟菌和引起淋病的淋病奈瑟菌。数学模型已被用于模拟它们的传播和控制策略，最近观察到B群脑膜炎球菌（MenB）疫苗对淋病有部分疗效，这引发了人们对建模的更多兴趣。在此，我们对文献进行了系统综述，重点关注模拟使用MenB疫苗预防奈瑟菌感染发病率和抗菌药物耐药性的疫苗接种策略的研究。通过期刊、预印本和灰色文献库，我们确定了52项研究，并对其有效性、模型方法和假设进行了综述。大多数研究显示证据质量良好，方法的多样性以及不同的建模角度尤其为淋病研究提供了保障。我们确定了未来研究的方向，包括在研究中将脑膜炎球菌感染和淋球菌感染结合起来，以便更好地评估疫苗的益处，以及淋病感染在异性恋群体和男男性行为者群体之间的交叉传播。然后，可以像针对脑膜炎球菌疾病那样，利用针对高危人群和更广泛人群的成本效益研究，为淋病疫苗政策提供参考。
