Movsisyan Vernon Ani S, Fejerman Laura, Hoch Jeffrey S, Keegan Theresa H
Department of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, USA; UC Davis Comprehensive Cancer Center, 2279 45(th) Street, Sacramento, CA 95817, USA.
Department of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, USA; Center for Healthcare Policy and Research, University of California, Davis, 4900 Broadway, Suite 1430, Sacramento, CA 95820, USA.
Prev Med. 2025 Feb;191:108214. doi: 10.1016/j.ypmed.2024.108214. Epub 2024 Dec 31.
To observe stage at diagnosis and cancer-specific survival for common cancers among Armenians in California.
We used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with stomach, lung, colorectal, and bladder cancers diagnosed during 1988-2019. We used multivariable logistic regression models to calculate odds of late-stage diagnoses among Armenian and non-Armenian, non-Hispanic White patients and examine the association of sociodemographic factors with late-stage diagnoses among the Armenian patient population. We used Cox proportional hazards models to calculate cancer-specific survival among Armenian patients compared to non-Armenian, non-Hispanic White patients.
Of the 639,224 cancer diagnoses identified, 6642 were among Armenian patients. Armenian individuals were more likely to be diagnosed with late-stage colorectal (OR = 1.12, 95 % CI = 1.03-1.22), lung (OR = 1.26, 95 % CI = 1.12-1.42), and stomach (OR = 1.43, 95 % CI = 1.17-1.74) cancers. Among Armenian patients, low nSES and public insurance were associated with late-stage diagnoses. Armenian individuals had better survival than non-Armenian, non-Hispanic White individuals for stomach (HR = 0.85, 95 % CI = 0.76-0.94), lung (HR = 0.86, 95 % CI = 0.82-0.91), colorectal (HR = 0.82, 95 % CI = 0.77-0.88), and bladder (HR = 0.87, 95 % CI = 0.76-0.99) cancers.
While Armenian patients were at greater risk of late-stage diagnoses of colorectal, lung, and stomach cancers, they had better survival compared to non-Armenian, non-Hispanic White patients. Further research is needed to understand factors impacting survival in Armenian individuals, including genetic, behavioral, and social factors. Our findings of lower nSES and public health insurance associated with late-stage diagnoses suggest a need for increased access to care and cancer screening among the Armenian population in California.
观察加利福尼亚州亚美尼亚人常见癌症的诊断阶段和癌症特异性生存率。
我们利用加利福尼亚癌症登记处的亚美尼亚姓氏列表和出生地信息，识别出1988年至2019年期间被诊断为胃癌、肺癌、结直肠癌和膀胱癌的亚美尼亚人。我们使用多变量逻辑回归模型计算亚美尼亚人和非亚美尼亚、非西班牙裔白人患者晚期诊断的几率，并研究社会人口学因素与亚美尼亚患者群体中晚期诊断的关联。我们使用Cox比例风险模型计算亚美尼亚患者与非亚美尼亚、非西班牙裔白人患者相比的癌症特异性生存率。
在确定的639224例癌症诊断中，亚美尼亚患者有6642例。亚美尼亚人更有可能被诊断为晚期结直肠癌（比值比=1.12，95%置信区间=1.03-1.22）、肺癌（比值比=1.26，95%置信区间=1.12-1.42）和胃癌（比值比=1.43，95%置信区间=1.17-1.74）。在亚美尼亚患者中，低社会经济地位和公共保险与晚期诊断相关。亚美尼亚人在胃癌（风险比=0.85，95%置信区间=0.76-0.94）肺癌（风险比=0.86，95%置信区间=0.82-0.91）、结直肠癌（风险比=0.82，95%置信区间=0.77-0.88）和膀胱癌（风险比=0.87，95%置信区间=0.76-0.99）方面的生存率高于非亚美尼亚、非西班牙裔白人。
虽然亚美尼亚患者患晚期结直肠癌、肺癌和胃癌的风险更高，但与非亚美尼亚、非西班牙裔白人患者相比，他们的生存率更高。需要进一步研究以了解影响亚美尼亚人生存率的因素，包括遗传、行为和社会因素。我们发现低社会经济地位和公共医疗保险与晚期诊断相关，这表明加利福尼亚州的亚美尼亚人群需要更多的医疗服务和癌症筛查机会。
