Guo Xianping, Zhu Xiaoli
Southeast University Medical College, Nanjing 210009, China.
Department of Respiratory, Southeast University Affiliated Zhongda Hospital, Nanjing 210009, China.
Respir Med. 2025 Feb;237:107938. doi: 10.1016/j.rmed.2024.107938. Epub 2025 Jan 1.
With the widespread use of Low-dose computed tomography (LDCT) in the chest, more and more people will be detected with pulmonary nodules. The presence of uncertainty following the detection of these nodules can impose significant psychological distress. This study aimed to investigate personality traits, psychological distress, and their impact on pulmonary nodule patients in China.
We conducted a cross-sectional survey of adults with pulmonary nodules accidently discovered by LDCT in the chest from the respiratory outpatient department.
A total of 224 patients with pulmonary nodules were included in this study. The prevalence of anxiety among patients with pulmonary nodules was found to be 47.8 %, while the prevalence of depression was reported to be 44.2 %. The present study also demonstrated a higher prevalence of anxiety among female patients with pulmonary nodules compared to their male counterparts, with mild anxiety being the predominant manifestation. The multivariate logistic regression analysis revealed that age (OR = 0.926, P < 0.01), gender (OR = 3.24, P < 0.01), number of pulmonary nodules (OR = 0.586, P < 0.05), lung cancer-related characteristics (OR = 5.423, P < 0.01), PTSD (OR = 5.715, P < 0.01), and Extroversion personality traits (OR = 1.087, P < 0.05) were significant factors contributing to anxiety in patients with pulmonary nodules. Similarly, (OR = 0.891, P < 0.01), gender (OR = 2.981, P < 0.05), duration (OR = 0.663, P < 0.05), lung cancer-related characteristics (OR = 5.707, P < 0.01), PTSD (OR = 4.420, P < 0.01)emerged as key factors associated with depression in this patient population.
Approximately 50 % of patients with pulmonary nodules exhibit negative affective states. Furthermore, as time progresses, the negative emotional burden of anxiety and depression in individuals with pulmonary nodules tends to alleviate.
随着低剂量计算机断层扫描（LDCT）在胸部检查中的广泛应用，越来越多的人被检测出肺部有结节。这些结节被检测出后存在的不确定性会给患者带来极大的心理困扰。本研究旨在调查中国肺部结节患者的人格特质、心理困扰及其影响。
我们对呼吸内科门诊中通过LDCT意外发现胸部有肺部结节的成年人进行了横断面调查。
本研究共纳入224例肺部结节患者。发现肺部结节患者的焦虑患病率为47.8%，而抑郁患病率为44.2%。本研究还表明，女性肺部结节患者的焦虑患病率高于男性患者，以轻度焦虑为主。多因素逻辑回归分析显示，年龄（OR = 0.926，P < 0.01）、性别（OR = 3.24，P < 0.01）、肺部结节数量（OR = 0.586，P < 0.05）、肺癌相关特征（OR = 5.423，P < 0.01）、创伤后应激障碍（PTSD）（OR = 5.715，P < 0.01）和外向型人格特质（OR = 1.087，P < 0.05）是导致肺部结节患者焦虑的重要因素。同样，（OR = 0.891，P < 0.01）、性别（OR = 2.981，P < 0.05）、病程（OR = 0.663，P < 0.05）、肺癌相关特征（OR = 5.707，P < 0.01）、创伤后应激障碍（OR = 4.420，P < 0.01）是该患者群体中与抑郁相关的关键因素。
约50%的肺部结节患者表现出消极情绪状态。此外，随着时间的推移，肺部结节患者焦虑和抑郁的负面情绪负担趋于减轻。
