Nudleman K L, Choi B, Kusske J A
Neurosurgery. 1985 Jan;16(1):90-5.
A 60-year-old woman presented with a history of headache and rapidly progressive complete bilateral ophthalmoplegia. Her endocrine function was normal. Radiographic studies revealed signs of diffuse destruction of the sella turcica by a tumor without suprasellar extension. Biopsies of the lesion within the sphenoid sinus demonstrated the presence of a primary pituitary carcinoma; autopsy findings revealed metastatic deposits in the liver, kidney, and lung. The histological characteristics of these cells and the electron microscopic findings confirmed that the tumor can first manifest themselves by the rapid development of unilateral or bilateral ophthalmoplegia; this diagnosis should be considered in all individuals with such a syndrome.
一名60岁女性，有头痛病史，并迅速进展为完全性双侧眼肌麻痹。其内分泌功能正常。影像学研究显示蝶鞍被肿瘤弥漫性破坏，但无鞍上扩展迹象。蝶窦内病变活检显示为原发性垂体癌；尸检发现肝脏、肾脏和肺部有转移灶。这些细胞的组织学特征和电子显微镜检查结果证实，该肿瘤可首先表现为单侧或双侧眼肌麻痹的快速发展；所有出现这种综合征的个体都应考虑这一诊断。
