Krishna Abhishek, Makkapatti Bharat Sai, Athiyamaan M S, Lobo Dilson, Srinivas Challapalli, Sunny Johan, Jawahar Vaishak, Kaur Harleen, Banerjee Sourjya
Department of Radiation Oncology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.
Radiat Oncol J. 2024 Dec;42(4):257-262. doi: 10.3857/roj.2023.01025. Epub 2024 Oct 25.
Cervical cancer is a significant global health issue affecting approximately 600,000 women each year. This study aimed to address the knowledge gaps surrounding the influence of treatment time parameters, including the duration of external beam radiotherapy (EBRT) to brachytherapy and overall treatment duration, on early recurrences.
Details on demographics, tumor characteristics, treatment details, and outcomes in patients undergoing chemoradiation and brachytherapy for cervical cancer were collected from the medical records. Early recurrence was defined as tumor reappearance within 6 months after treatment in patients with an initial complete response. Statistical analyses included descriptive statistics chi-square tests, independent t-tests, and logistic regression.
A total of 288 cervical cancer patients were included. Stage IIB was the most common stage and 93% of patients had a complete response, 4.5% partial response, and 3.1% had progressive disease at 3rd month. At 6 months, 8% experienced early. The average interval between EBRT and brachytherapy was 10.4 ± 4.2 days among the no recurrence group and 12.3 ± 4.5 days among early recurrence group. A total of 203 patients had a gap of 10 or fewer days and 123 patients had a gap of more than 10 days between EBRT and brachytherapy. Difference was observed in the overall treatment time between the two groups had significant differences (no recurrence group, 61.6 ± 11.5 days; early recurrence group, 73.8 ± 8.8 days; p < 0.001).
The study revealed that longer overall treatment durations were associated with a higher risk of early recurrences, highlighting the need for further investigation and optimized treatment strategies.
宫颈癌是一个重大的全球健康问题，每年影响约60万名女性。本研究旨在解决围绕治疗时间参数（包括外照射放疗（EBRT）至近距离放疗的持续时间和总体治疗持续时间）对早期复发影响的知识空白。
从病历中收集接受宫颈癌放化疗和近距离放疗患者的人口统计学、肿瘤特征、治疗细节及结果等详细信息。早期复发定义为初始完全缓解的患者在治疗后6个月内肿瘤再次出现。统计分析包括描述性统计、卡方检验、独立t检验和逻辑回归。
共纳入288例宫颈癌患者。IIB期是最常见的分期，93%的患者在第3个月时有完全缓解，4.5%部分缓解，3.1%病情进展。在6个月时，8%的患者出现早期复发。无复发组EBRT与近距离放疗的平均间隔为10.4±4.2天，早期复发组为12.3±4.5天。共有203例患者EBRT与近距离放疗间隔为10天或更短，123例患者间隔超过10天。两组在总体治疗时间上存在差异，具有显著统计学意义（无复发组，61.6±11.5天；早期复发组，73.8±8.8天；p<0.001）。
该研究表明，更长的总体治疗持续时间与更高的早期复发风险相关，凸显了进一步研究和优化治疗策略的必要性。
