Cserni Gábor
Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary.
Department of Pathology, Albert Szent-Györgyi Faculty of Medicine, University of Szeged, Szeged, Hungary.
Pathologica. 2024 Oct;116(5):273-284. doi: 10.32074/1591-951X-1043.
Invasive lobular carcinoma of the breast is the most common special type breast cancer. It has been defined using morphological features, has a characteristic immunophenotype associated with the loss of E-cadherin mediated intercellular adhesion, and the background of this immunohistochemistry and morphology is generally a biallelic genetic alteration of the CDH-1 gene coding E-cadherin. However, the morphology may often deviate from the classical, and immunohistochemistry may also deviate from the typical, and then the diagnosis of invasive lobular carcinoma becomes less straight forward. Eventually, the definitions of this histological type, although similar, are not identical and this may also give ground to occasional different interpretations. This review summarizes different approaches to invasive lobular carcinomas and the deviations from what is considered normal.
乳腺浸润性小叶癌是最常见的特殊类型乳腺癌。它通过形态学特征来定义，具有与E-钙黏蛋白介导的细胞间黏附丧失相关的特征性免疫表型，这种免疫组化和形态学的背景通常是编码E-钙黏蛋白的CDH-1基因的双等位基因遗传改变。然而，其形态学常常偏离经典表现，免疫组化也可能与典型情况不同，进而使浸润性小叶癌的诊断变得不那么直接。最终，这种组织学类型的定义虽然相似，但并不完全相同，这也可能导致偶尔出现不同的解读。本综述总结了浸润性小叶癌的不同诊断方法以及与正常情况的偏差。
