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肾细胞癌中泛素化修饰的失调

Dysregulation of ubiquitination modification in renal cell carcinoma.

作者信息

You Hongjie, Zhang Hui, Jin Xiaofeng, Yan Zejun

机构信息

Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.

出版信息

Front Genet. 2024 Dec 19;15:1453191. doi: 10.3389/fgene.2024.1453191. eCollection 2024.

DOI:10.3389/fgene.2024.1453191
PMID:39748950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11693700/
Abstract

Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases. Additionally, we discuss research progress in RCC treatment by targeting key enzymes related to ubiquitination modifications.

摘要

肾细胞癌（RCC）是一种肾小管上皮细胞的恶性肿瘤，在全球范围内发病率相对较高。大量研究表明，泛素化失调，包括泛素化和去泛素化异常，与肾细胞癌的发生发展有关。本综述重点关注由E3连接酶和去泛素化酶引起的几种异常信号通路。此外，我们还讨论了通过靶向与泛素化修饰相关的关键酶来治疗肾细胞癌的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/4467cf2e87e9/fgene-15-1453191-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/b72b12e71e31/fgene-15-1453191-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/f4777f8dda90/fgene-15-1453191-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/d9afd6c37732/fgene-15-1453191-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/e6b472896499/fgene-15-1453191-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/63ac569dc194/fgene-15-1453191-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/cf1ce2422e5f/fgene-15-1453191-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/eb8d5f630dd0/fgene-15-1453191-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/16589af4c0b5/fgene-15-1453191-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/4467cf2e87e9/fgene-15-1453191-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/b72b12e71e31/fgene-15-1453191-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/f4777f8dda90/fgene-15-1453191-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/d9afd6c37732/fgene-15-1453191-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/e6b472896499/fgene-15-1453191-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/63ac569dc194/fgene-15-1453191-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/cf1ce2422e5f/fgene-15-1453191-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/eb8d5f630dd0/fgene-15-1453191-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/16589af4c0b5/fgene-15-1453191-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a89/11693700/4467cf2e87e9/fgene-15-1453191-g009.jpg

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