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新型冠状病毒肺炎所致中毒性表皮坏死松解症

Toxic epidermal necrolysis induced by COVID-19.

作者信息

Alahmadi Duaa, Ahmed Azhar, Shaheen Esraa, Ozbuk Ahmed, Borhan Wala

机构信息

Ministry of Health, Medinah.

King Fahad General Hospital, Madinah.

出版信息

Dermatol Reports. 2024 Jan 30;16(4):9853. doi: 10.4081/dr.2024.9853. eCollection 2024 Nov 21.

DOI:10.4081/dr.2024.9853
PMID:39749117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11694420/
Abstract

Toxic epidermal necrolysis (TEN) is a life-threatening acute mucocutaneous syndrome. It is characterized by keratinocyte necrosis and apoptosis, which affect more than 30% of the body's surface. TEN is most commonly due to an altered immunological response to specific drugs, infections, and malignancies, or it can be idiopathic. The combination of TEN and COVID-19 can have a fatal outcome if not recognized and promptly treated. Therefore, fast reporting of such cases will draw doctors' attention to quick and right intervention. In this article, we present a 66-year-old patient with a clinical presentation of toxic epidermal necrolysis along with a coexisting COVID-19 infection. To our knowledge, this is the first case of TEN in a patient diagnosed with SARS CoV-2 infection in Saudi Arabia.

摘要

中毒性表皮坏死松解症（TEN）是一种危及生命的急性黏膜皮肤综合征。其特征为角质形成细胞坏死和凋亡，累及身体表面超过30%的面积。TEN最常见的病因是对特定药物、感染和恶性肿瘤的免疫反应改变，也可能是特发性的。如果未被识别并及时治疗，TEN与新冠肺炎的合并感染可能会导致致命后果。因此，快速报告此类病例将引起医生对迅速且正确干预的关注。在本文中，我们介绍了一名66岁的患者，其临床表现为中毒性表皮坏死松解症并合并新冠肺炎感染。据我们所知，这是沙特阿拉伯首例被诊断为感染新型冠状病毒2的患者出现TEN的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/8b31c6027e74/dr-16-4-9853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/9fe562272f8c/dr-16-4-9853-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/8b31c6027e74/dr-16-4-9853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/9fe562272f8c/dr-16-4-9853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/65962777f2e4/dr-16-4-9853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/fc293aee6976/dr-16-4-9853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/2927a9467bbf/dr-16-4-9853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55cc/11694420/8b31c6027e74/dr-16-4-9853-g005.jpg

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本文引用的文献

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Australas J Dermatol. 2023 Feb;64(1):e1-e10. doi: 10.1111/ajd.13958. Epub 2022 Dec 9.
2
Toxic Epidermal Necrolysis associated with COVID-19 infection: A case report.与新型冠状病毒肺炎感染相关的中毒性表皮坏死松解症：一例报告
Clin Case Rep. 2022 Mar 13;10(3):e05565. doi: 10.1002/ccr3.5565. eCollection 2022 Mar.
3
Increased Predisposition of SJS TEN in COVID-19 Patients, Presenting as Post COVID Complication: Report of Two Cases.
新冠病毒感染患者发生中毒性表皮坏死松解症和史蒂文斯-约翰逊综合征的易感性增加，表现为新冠后并发症：两例报告
Indian Dermatol Online J. 2022 Mar 3;13(2):237-239. doi: 10.4103/idoj.idoj_510_21. eCollection 2022 Mar-Apr.
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COVID-19-induced toxic epidermal necrolysis.新型冠状病毒肺炎所致中毒性表皮坏死松解症
Clin Exp Dermatol. 2021 Jul;46(5):927-929. doi: 10.1111/ced.14574. Epub 2021 Feb 19.
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Challenges in the treatment of a patient with toxic epidermal necrolysis associated with COVID-19: A case report.新型冠状病毒肺炎相关中毒性表皮坏死松解症患者的治疗挑战：一例报告
Dermatol Ther. 2021 Jan;34(1):e14656. doi: 10.1111/dth.14656. Epub 2020 Dec 15.
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Dermatol Res Pract. 2020 Oct 9;2020:7524726. doi: 10.1155/2020/7524726. eCollection 2020.
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