Mogensen Christina Sonne, Magkos Faidon, Chabanova Elizaveta, Mølgaard Christian, Geiker Nina Rica Wium
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Department of Radiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark.
Obesity (Silver Spring). 2025 Feb;33(2):238-242. doi: 10.1002/oby.24176. Epub 2025 Jan 3.
The study objective was to evaluate changes in abdominal adipose tissue and ectopic fat during pregnancy and their associations with gestational weight gain (GWG) in women with overweight/obesity.
This study was a secondary analysis of a randomized controlled trial. Magnetic resonance scans were performed during gestational week (GW) 15, GW 32, and around birth to measure abdominal subcutaneous (SAT) and visceral (VAT) adipose tissues, liver fat, and muscle fat. Linear mixed models and multivariable linear regression analyses were utilized, adjusting for prepregnancy BMI, parity, and randomization.
Among 119 women, VAT and SAT decreased from GW 15 to GW 32 but rebounded at birth; final levels were lower than at GW 15. Liver fat and muscle fat did not change significantly. GWG was positively associated with changes in SAT but not with those in VAT, liver fat, or muscle fat.
This study demonstrates dynamic changes in abdominal fat depots during pregnancy in women with overweight/obesity. The observed reduction in VAT and SAT during pregnancy and the association of GWG with SAT suggest that weight gain during pregnancy may be less metabolically harmful than outside pregnancy. Future research should investigate the mechanisms and long-term effects on maternal and child health.
本研究的目的是评估超重/肥胖女性在孕期腹部脂肪组织和异位脂肪的变化及其与孕期体重增加（GWG）的关联。
本研究是一项随机对照试验的二次分析。在妊娠第15周、第32周以及临近分娩时进行磁共振扫描，以测量腹部皮下（SAT）和内脏（VAT）脂肪组织、肝脏脂肪和肌肉脂肪。采用线性混合模型和多变量线性回归分析，并对孕前体重指数、产次和随机分组进行了校正。
在119名女性中，VAT和SAT从妊娠第15周降至第32周，但在分娩时反弹；最终水平低于第15周。肝脏脂肪和肌肉脂肪无显著变化。GWG与SAT的变化呈正相关，但与VAT、肝脏脂肪或肌肉脂肪的变化无关。
本研究表明超重/肥胖女性在孕期腹部脂肪库存在动态变化。孕期观察到的VAT和SAT减少以及GWG与SAT的关联表明，孕期体重增加可能比孕期外的体重增加对代谢的危害更小。未来的研究应调查其机制以及对母婴健康的长期影响。
