Akaishi T, Sakuma Y
Neurosci Lett. 1985 Feb 28;54(1):91-6. doi: 10.1016/s0304-3940(85)80123-3.
One-hundred and ten paraventricular (PV) neurosecretory cells were identified antidromically in castrated male rats anesthetized with urethane. After classifying the antidromically driven units into tonically and phasically firing groups, the latency, threshold, relative refractory period and wave form of the antidromic response were studied. Estradiol and testosterone had no effect on these parameters or on the wave form of antidromic responses in both cell groups. Testosterone caused a significant acceleration of the mean firing rate of the tonically firing cells (from 2.9 +/- 0.6 to 5.1 +/- 0.5 Hz) but estradiol did not affect it. These observations suggest that testosterone modulates the basal firing activity of the tonically firing PV neurosecretory cells in the male rat.
在用乌拉坦麻醉的去势雄性大鼠中，通过逆向刺激鉴定出110个室旁（PV）神经分泌细胞。将逆向驱动的单位分为紧张性放电组和相位性放电组后，研究了逆向反应的潜伏期、阈值、相对不应期和波形。雌二醇和睾酮对这两组细胞的这些参数或逆向反应的波形均无影响。睾酮使紧张性放电细胞的平均放电频率显著加快（从2.9±0.6Hz增至5.1±0.5Hz），但雌二醇对此无影响。这些观察结果表明，睾酮可调节雄性大鼠中紧张性放电的PV神经分泌细胞的基础放电活动。
