循环CD3CD8 T淋巴细胞作为早期乳腺癌患者疾病状态的指标
Circulating CD3CD8 T Lymphocytes as Indicators of Disease Status in Patients With Early Breast Cancer.
作者信息
Chen Han-Kun, Chen Yi-Ling, Chung Wei-Pang, Loh Zhu-Jun, Lee Kuo-Ting, Hsu Hui-Ping
机构信息
Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Department of Nursing, Meiho University, Pingtung, Taiwan.
出版信息
Cancer Med. 2025 Jan;14(1):e70547. doi: 10.1002/cam4.70547.
Circulating CD3CD8 cell levels were lower in breast cancer patients, elevated posttreatment, and subsequently declining upon recurrence. Elevated plasma chemokine (C-C motif) ligand 2 (CCL2) levels distinguished patients with breast cancer from healthy controls. In summary, circulating CD3CD8 CTL and plasma CCL2 levels emerged as promising dual-purpose biomarkers and therapeutic targets in breast cancer management.
乳腺癌患者循环CD3CD8细胞水平较低，治疗后升高，随后在复发时下降。血浆趋化因子（C-C基序）配体2（CCL2）水平升高可区分乳腺癌患者与健康对照。总之，循环CD3CD8细胞毒性T淋巴细胞（CTL）和血浆CCL2水平有望成为乳腺癌管理中有前景的双重生物标志物和治疗靶点。
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