Neĭfakh A A
Ontogenez. 1985 Jan-Feb;16(1):15-25.
Two closely related controversial problems are discussed: whether the developmental processes can be reduced to the synthesis of polypeptides encoded in DNA, and whether the information in DNA is equivalent to that in the adult organism. Critically considered are the ideas that DNA is only responsible for the protein synthesis, whereas morphogenesis proceeds independently and according to epigenetic regularities of its own. It is stated that development is the realization of genetic information in which more elementary (molecular) processes unambiguously determine a more complex cellular level which in its turn determines morphogenesis of tissues and organs. Various mechanisms of the appearance of new information in the course of development are considered. The statement is made that new information concerns only some individual characters of the organism, whereas most of information that determines the process of development and the structure of the adult organism is created in the course of evolution, is stored in DNA and inherited.
发育过程是否可以简化为DNA编码的多肽合成，以及DNA中的信息是否等同于成年生物体中的信息。批判性地考虑了以下观点：DNA仅负责蛋白质合成，而形态发生则独立进行并遵循其自身的表观遗传规律。文章指出，发育是遗传信息的实现，其中更基本的（分子）过程明确地决定了更复杂的细胞水平，而细胞水平又反过来决定组织和器官的形态发生。文中还考虑了发育过程中出现新信息的各种机制。文章指出，新信息仅涉及生物体的某些个体特征，而决定发育过程和成年生物体结构的大部分信息是在进化过程中产生的，存储在DNA中并遗传下来。
