Willocx Daan, Diamanti Eleonora, Hirsch Anna K H
Helmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Saar-land University, Campus E8.1, 66123Saarbrücken, Germany.
Department of Pharmacy, Saarland University, Campus E8.1, 66123Saarbrücken, Germany.
J Med Chem. 2025 Jan 23;68(2):886-901. doi: 10.1021/acs.jmedchem.4c01146. Epub 2025 Jan 3.
Antimicrobial resistance (AMR) and herbicide resistance pose threats to society, necessitating novel anti-infectives and herbicides exploiting untapped modes of action like inhibition of IspD, the third enzyme in the MEP pathway. The MEP pathway is essential for a wide variety of human pathogens, including , , and as well as plants. Within the current perspective, we focused our attention on the third enzyme in this pathway, IspD, offering a comprehensive summary of the reported modes of inhibition and common trends, with the goal to inspire future research dedicated to this underexplored target. In addition, we included an overview of the history, catalytic mechanism, and structure of the enzyme to facilitate access to this attractive target.
抗菌药物耐药性（AMR）和除草剂耐药性对社会构成威胁，因此需要开发利用未开发作用模式的新型抗感染药物和除草剂，例如抑制MEP途径中的第三种酶IspD。MEP途径对于包括[此处原文未列出具体病原体名称]、[此处原文未列出具体病原体名称]和[此处原文未列出具体病原体名称]以及植物在内的多种人类病原体至关重要。在当前的视角下，我们将注意力集中在该途径中的第三种酶IspD上，全面总结了已报道的抑制模式和共同趋势，目的是激发针对这个未充分探索靶点的未来研究。此外，我们还概述了该酶的历史、催化机制和结构，以便于研究这个有吸引力的靶点。
