Zhuang Xianbo, Lin Jie, Song Yamin, Ban Ru, Zhao Xin, Xia Zhangyong, Wang Zheng, Zhang Guifeng
Department of Neurology, Liaocheng People's Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, 252000, China.
School of Basic Medicine Sciences, Shandong University, Jinan, China.
Neuromolecular Med. 2024 Dec 29;27(1):2. doi: 10.1007/s12017-024-08815-z.
Alzheimer's disease (AD) is a common progressive neurodegenerative disorder, and the vast majority of cases occur in elderly patients. Recently, the accumulation of Aβ and tau proteins has drawn considerable attention in AD research. This review explores the multifaceted interactions between these proteins and their contribution to the pathological landscape of AD, encompassing synaptic dysfunction, neuroinflammation, and PANoptosis. PANoptosis is a collective term for programmed cell death (PCD) modalities that encompass elements of apoptosis, pyroptosis, and necroptosis. The accumulation of Aβ peptides and tau proteins, along with the immune response in brain cells, may trigger PANoptosis, thus advancing the progression of the disease. Recent advancements in molecular imaging and genetics have provided deeper insights into the interactions between Aβ peptides, tau proteins, and the immune response. The review also discusses the role of mitochondrial dysregulation in AD. The exploration of the interplay between neurodegeneration, immune responses, and cell death offers promising avenues for the development of innovative treatments.
阿尔茨海默病（AD）是一种常见的进行性神经退行性疾病，绝大多数病例发生在老年患者中。最近，Aβ和tau蛋白的积累在AD研究中引起了相当大的关注。本综述探讨了这些蛋白之间的多方面相互作用及其对AD病理格局的影响，包括突触功能障碍、神经炎症和PAN细胞焦亡。PAN细胞焦亡是一个统称，指的是程序性细胞死亡（PCD）模式，包括凋亡、细胞焦亡和坏死性凋亡的成分。Aβ肽和tau蛋白的积累，以及脑细胞中的免疫反应，可能会触发PAN细胞焦亡，从而推动疾病的进展。分子成像和遗传学方面的最新进展为深入了解Aβ肽、tau蛋白和免疫反应之间的相互作用提供了帮助。本综述还讨论了线粒体功能失调在AD中的作用。对神经退行性变、免疫反应和细胞死亡之间相互作用的探索为创新治疗方法的开发提供了有前景的途径。
