Frimodt-Møller P C, Dørflinger T, Madsen P O
Prostate. 1985;6(2):163-8. doi: 10.1002/pros.2990060206.
Constant infusion experiments with amifloxacin, a quinoline carboxylic acid derivative, were performed in five anesthetized dogs to determine the drug concentrations in prostatic secretion (PS), prostatic interstitial fluid (PIF), prostatic tissue, and plasma (P). The experiments were carried out under steady-state conditions. Amifloxacin concentrations in PS and PIF were lower than the corresponding P concentrations, as might be expected for an acid compound. There was no significant difference between the PS/P and PIF/P concentration ratios of the drug, and none exceeded 1.0. The concentrations of amifloxacin in PS, PIF, and prostatic tissue were above the minimal inhibitory concentration values of most gram-positive bacteria causing chronic bacterial prostatitis. Clinical trials of amifloxacin seem justified.
对五只麻醉犬进行了喹啉羧酸衍生物阿米氟沙星的持续输注实验，以测定前列腺分泌物（PS）、前列腺间质液（PIF）、前列腺组织和血浆（P）中的药物浓度。实验在稳态条件下进行。正如酸性化合物所预期的那样，PS和PIF中的阿米氟沙星浓度低于相应的血浆浓度。该药物的PS/血浆和PIF/血浆浓度比值之间无显著差异，且均未超过1.0。PS、PIF和前列腺组织中的阿米氟沙星浓度高于大多数引起慢性细菌性前列腺炎的革兰氏阳性菌的最低抑菌浓度值。阿米氟沙星的临床试验似乎是合理的。
