Qin Lexin, Liang Tingting, Zhu Xinyu, Hu Wentao, Li Bo, Wei Meidan, Zhang Jiaxin, Li Jianxiang, Wang Jin
Aging Dis. 2024 Dec 31. doi: 10.14336/AD.2024.1404.
Lung cancer treatment is evolving, and the role of senescent macrophages in tumor immune evasion has become a key focus. This study explores how senescent macrophages interact with lung cancer cells, contributing to tumor progression and immune dysfunction. As aging impairs macrophage functions, including phagocytosis and metabolic signaling, it promotes chronic inflammation and cancer development. p16-positive macrophages are common in aged mice, and their clearance slows tumor growth, suggesting these cells support tumor proliferation and immune evasion. Targeting the senescence-associated secretory phenotype (SASP) and reprogramming senescent macrophages offers potential therapeutic benefits, including reversing immune aging and boosting anti-tumor immunity. However, translating these findings into clinical practice requires further molecular understanding and rigorous clinical trials.
肺癌治疗正在不断发展，衰老巨噬细胞在肿瘤免疫逃逸中的作用已成为关键焦点。本研究探讨衰老巨噬细胞如何与肺癌细胞相互作用，促进肿瘤进展和免疫功能障碍。随着衰老损害巨噬细胞功能，包括吞噬作用和代谢信号传导，它会促进慢性炎症和癌症发展。p16阳性巨噬细胞在老年小鼠中很常见，清除它们可减缓肿瘤生长，表明这些细胞支持肿瘤增殖和免疫逃逸。靶向衰老相关分泌表型（SASP）并对衰老巨噬细胞进行重编程具有潜在的治疗益处，包括逆转免疫衰老和增强抗肿瘤免疫力。然而，将这些发现转化为临床实践需要进一步的分子理解和严格的临床试验。
