Sun Shunan, Chen Yu, Ouyang Yuzhen, Tang Zhenwei
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, People's Republic of China.
Zhejiang University School of Medicine, Hangzhou, China.
Clin Rev Allergy Immunol. 2024 Dec 30;68(1):2. doi: 10.1007/s12016-024-09011-4.
The switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes (also referred to as BAF complexes) are composed of multiple subunits, which regulate the nucleosome translocation and chromatin accessibility. In recent years, significant advancements have been made in understanding mutated genes encoding subunits of the SWI/SNF complexes in cancer biology. Nevertheless, the role of SWI/SNF complexes in immune response and inflammatory diseases continues to attract significant attention. This review presents a summary of the significant functions of SWI/SNF complexes during the overall process from the development to the activation of innate and adaptive immune cells. In addition, the correlation between various SWI/SNF subunits and diverse inflammatory diseases is explored. Further investigations are warranted in terms of the mechanism of SWI/SNF complexes' preference for binding sites and opposite pro-/anti-inflammatory effects. In conclusion, further efforts are needed to evaluate the druggability of targeting SWI/SNF complexes in inflammatory diseases, and we hope this review will inspire the development of novel immune modulators in clinical practice.
开关/蔗糖非发酵型（SWI/SNF）染色质重塑复合物（也称为BAF复合物）由多个亚基组成，这些亚基调节核小体易位和染色质可及性。近年来，在癌症生物学中对编码SWI/SNF复合物亚基的突变基因的理解取得了重大进展。然而，SWI/SNF复合物在免疫反应和炎症性疾病中的作用仍然备受关注。本综述总结了SWI/SNF复合物在先天和适应性免疫细胞从发育到激活的整个过程中的重要功能。此外，还探讨了各种SWI/SNF亚基与多种炎症性疾病之间的相关性。关于SWI/SNF复合物对结合位点的偏好机制以及相反的促炎/抗炎作用，还需要进一步研究。总之，需要进一步努力评估在炎症性疾病中靶向SWI/SNF复合物的可成药性，我们希望本综述能激发临床实践中新型免疫调节剂的开发。
