• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1.

作者信息

Lin Xiaowen, Zhao Lechen, Cai Heng, Chang Xiaohua, Tang Yuxuan, Luo Tianyu, Wu Mengdan, Yi Cuiying, Ma Limin, Chu Xiaojing, Han Shuo, Zhao Qiang, Wu Beili, He Maozhou, Zhu Ya

机构信息

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

出版信息

Protein Cell. 2025 May 28;16(5):381-385. doi: 10.1093/procel/pwae073.

DOI:10.1093/procel/pwae073
PMID:39752296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12120241/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0439/12120241/7a6b21ba39e3/pwae073_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0439/12120241/7a6b21ba39e3/pwae073_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0439/12120241/7a6b21ba39e3/pwae073_fig1.jpg

相似文献

1
Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1.对趋化素受体CMKLR1和GPR1独特的配体识别及信号传导的结构见解。
Protein Cell. 2025 May 28;16(5):381-385. doi: 10.1093/procel/pwae073.
2
The Chemerin Receptor CMKLR1 Requires Full-Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase-Based Binding Assay.趋化素受体 CMKLR1 需要全长趋化素才能具有高亲和力，这与 GPR1 不同，这一点通过新的基于纳米荧光素酶的结合测定得到了证明。
ChemMedChem. 2022 Dec 5;17(23):e202200413. doi: 10.1002/cmdc.202200413. Epub 2022 Oct 26.
3
CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway.CMKLR1和GPR1通过RhoA/ROCK信号通路介导凯莫瑞信号传导。
Mol Cell Endocrinol. 2015 Dec 5;417:36-51. doi: 10.1016/j.mce.2015.09.002. Epub 2015 Sep 9.
4
Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2.凯莫瑞蛋白受体CMKLR1、GPR1和CCRL2的信号传导特性
PLoS One. 2016 Oct 7;11(10):e0164179. doi: 10.1371/journal.pone.0164179. eCollection 2016.
5
Structural Basis for Chemerin Recognition and Signaling Through Its Receptors.通过其受体识别和信号传导的凯莫瑞蛋白的结构基础。
Biomedicines. 2024 Oct 28;12(11):2470. doi: 10.3390/biomedicines12112470.
6
Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.在人和大鼠血管中，chemerin通过趋化因子样受体1（CMKLR1）而非G蛋白偶联受体1（GPR1）引发强烈的收缩作用。
J Am Heart Assoc. 2016 Oct 14;5(10):e004421. doi: 10.1161/JAHA.116.004421.
7
Ex vivo analysis of serum chemerin activity in murine models of obesity.肥胖症小鼠模型中血清 chemerin 活性的体外分析。
Cytokine. 2018 Apr;104:42-45. doi: 10.1016/j.cyto.2018.02.004. Epub 2018 Feb 6.
8
The expression of chemerin and its receptors (CMKLR1, GPR1, CCRL2) in the porcine uterus during the oestrous cycle and early pregnancy and in trophoblasts and conceptuses.在发情周期和早期妊娠以及胎盘中，猪子宫中 chemerin 及其受体 (CMKLR1、GPR1、CCRL2) 的表达。
Animal. 2020 Oct;14(10):2116-2128. doi: 10.1017/S175173112000097X. Epub 2020 May 13.
9
International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin) and GPR1 (Chemerin) Nomenclature, Pharmacology, and Function.国际基础与临床药理学联合会CIII：凯莫瑞受体CMKLR1（凯莫瑞）和GPR1（凯莫瑞）命名、药理学及功能
Pharmacol Rev. 2018 Jan;70(1):174-196. doi: 10.1124/pr.116.013177. Epub 2017 Dec 26.
10
Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability and impairs tumor growth .抑制神经母细胞瘤细胞中的chemerin/CMKLR1轴可降低克隆形成能力和细胞活力，并损害肿瘤生长。
Oncotarget. 2017 Jul 27;8(56):95135-95151. doi: 10.18632/oncotarget.19619. eCollection 2017 Nov 10.

本文引用的文献

1
Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode.G 蛋白偶联受体 GPR1 与全长趋化素脂肪因子结合的结构揭示了一种类似趋化因子的反向结合模式。
PLoS Biol. 2024 Oct 28;22(10):e3002838. doi: 10.1371/journal.pbio.3002838. eCollection 2024 Oct.
2
Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist.趋化素受体 CMKLR1 激动剂诱导的 G 蛋白偶联受体激活和信号转导的结构基础。
PLoS Biol. 2023 Dec 6;21(12):e3002188. doi: 10.1371/journal.pbio.3002188. eCollection 2023 Dec.
3
Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
全长 Chemerin 的稳定结合由 CMKLR1 N 端的负电荷驱动。
Chembiochem. 2023 Sep 15;24(18):e202300280. doi: 10.1002/cbic.202300280. Epub 2023 Aug 9.
4
Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.人趋化素受体 1-Gi 蛋白复合物与趋化素 C 端九肽结合的冷冻电镜结构。
Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2214324120. doi: 10.1073/pnas.2214324120. Epub 2023 Mar 7.
5
Chemerin Forms: Their Generation and Activity.凯莫瑞蛋白的形式：其生成与活性
Biomedicines. 2022 Aug 19;10(8):2018. doi: 10.3390/biomedicines10082018.
6
Ligand-binding and -scavenging of the chemerin receptor GPR1.凯莫瑞蛋白受体GPR1的配体结合与清除
Cell Mol Life Sci. 2021 Sep;78(17-18):6265-6281. doi: 10.1007/s00018-021-03894-8. Epub 2021 Jul 9.
7
Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution.激动剂抗 ChemR23 mAb 减少组织中性粒细胞聚集并触发慢性炎症消退。
Sci Adv. 2021 Apr 2;7(14). doi: 10.1126/sciadv.abd1453. Print 2021 Apr.
8
Chemerin in inflammatory diseases.炎症性疾病中的凯莫瑞蛋白
Clin Chim Acta. 2021 Jun;517:41-47. doi: 10.1016/j.cca.2021.02.010. Epub 2021 Feb 23.
9
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.人卷曲蛋白 5 的结构通过基准辅助 cryo-EM 支持经典 Wnt 信号的异二聚体机制。
Elife. 2020 Aug 7;9:e58464. doi: 10.7554/eLife.58464.
10
Chemerin Isoforms and Activity in Obesity.肥胖症中趋化素同工型及其活性。
Int J Mol Sci. 2019 Mar 5;20(5):1128. doi: 10.3390/ijms20051128.